Lipoprotein lipase SNPs rs13702 and rs301 correlate with clinical outcome in chronic lymphocytic leukemia patients.

Ans Rombout
Basile Stamatopoulos
Laurence Lagneaux
Sofie Lust
Fritz Offner
Evelien Naessens
Hanne Vanderstraeten
Bruno Verhasselt
Jan Philippé

Open link

DOI

10.1371/journal.pone.0121526

Publisher

Public Library of Science (PLoS)

Journal

issn:1932-6203

Abstract

Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world and is characterized by a heterogeneous clinical course. This variability in clinical course has spiked the search for prognostic markers able to predict patient evolution at the moment of diagnosis. Markers demonstrated to be of value are the mutation status of the immunoglobulin heavy chain variable region genes (IGHV) and lipoprotein lipase (LPL) expression. High LPL mRNA expression has been associated with short treatment free (TFS) and decreased overall survival (OS) in CLL. The LPL SNPs rs301 (T<C), rs328 (C<G) and rs13702 (T<C) have been associated with various metabolic disorders, but the association with CLL evolution is unknown. Here, in a cohort o...