Dietary vitamin D3 supplements reduce demyelination in the cuprizone model.
- Stig Wergeland
- Øivind Torkildsen
- Kjell-Morten Myhr
- Lage Aksnes
- Sverre Jarl Mørk
- Lars Bø
DOIAbstract
Vitamin D is emerging as a probably important environmental risk factor in multiple sclerosis, affecting both susceptibility and disease progression. It is not known to what extent this effect is due to a modulation of peripheral lymphocyte function, or to intrathecal effects of vitamin D. We investigated the effect of dietary vitamin D3 content on de/remyelination in the cuprizone model, which is a well established toxic model of demyelination, with no associated lymphocyte infiltration. The mice received diets either deficient of (<50 IU/kg), or supplemented with low (500 IU/kg), high (6200 IU/kg) or very high (12500 IU/kg) amounts of vit D3. Cuprizone (0.2%) was added to the diet for six weeks, starting two weeks after onset of the exper...
Add to ORKG