BACKGROUND AND AIMS: The methylene-tetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (MTHFD1L) gene is involved in mitochondrial tetrahydrofolate metabolism. Polymorphisms in MTHFD1L, including rs6922269, have been implicated in risk for coronary artery disease (CAD). We investigated the association between rs6922269 and known metabolic risk factors and survival in two independent cohorts of coronary heart disease patients. METHODS AND RESULTS: DNA and plasma from 1940 patients with acute coronary syndromes were collected a median of 32 days after index hospital admission (Coronary Disease Cohort Study, CDCS). Samples from a validation cohort of 842 patients post-myocardial infarction (PMI) were taken 24-96 hours after hospitalization...
Background: The C677T mutation in methylenetetrahydrofolate reductase (MTHFR) gene is one of the cau...
Background: The C677T mutation in methylenetetrahydrofolate reductase (MTHFR) gene is one of the cau...
Elevated plasma total homocysteine (hcy), a risk factor for Coronary Artery Disease (CAD), is due to...
Background and Aims: The methylene-tetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (MTHFD1...
, including rs6922269, have been implicated in risk for coronary artery disease (CAD). We investigat...
Background and Aims: The methylene-tetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (MTHFD1L)...
Background: As the leading cause of death globally, cardiovascular disease (CVD) is a major public h...
Background: As the leading cause of death globally, cardiovascular disease (CVD) is a major public h...
Background: Methylenetetrahydrofolate dehydrogenase (MTHFD1) catalyzes three sequential reactions th...
Objectives Alterations in the enzymes involved in homocysteine (Hcy) metabolism or vitamin deficienc...
Objectives Alterations in the enzymes involved in homocysteine (Hcy) metabolism or vitamin deficienc...
AbstractBackgroundMethylenetetrahydrofolate dehydrogenase (MTHFD1) catalyzes three sequential reacti...
Background: In recent years, the interest in genetic predisposition studies for coronary artery dise...
AbstractObjectives. We sought to determine whether the C677T transition in the methylenetetrahydrofo...
Alterations in the enzymes involved in homocysteine (Hcy) metabolism or vitamin deficiency could pla...
Background: The C677T mutation in methylenetetrahydrofolate reductase (MTHFR) gene is one of the cau...
Background: The C677T mutation in methylenetetrahydrofolate reductase (MTHFR) gene is one of the cau...
Elevated plasma total homocysteine (hcy), a risk factor for Coronary Artery Disease (CAD), is due to...
Background and Aims: The methylene-tetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (MTHFD1...
, including rs6922269, have been implicated in risk for coronary artery disease (CAD). We investigat...
Background and Aims: The methylene-tetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (MTHFD1L)...
Background: As the leading cause of death globally, cardiovascular disease (CVD) is a major public h...
Background: As the leading cause of death globally, cardiovascular disease (CVD) is a major public h...
Background: Methylenetetrahydrofolate dehydrogenase (MTHFD1) catalyzes three sequential reactions th...
Objectives Alterations in the enzymes involved in homocysteine (Hcy) metabolism or vitamin deficienc...
Objectives Alterations in the enzymes involved in homocysteine (Hcy) metabolism or vitamin deficienc...
AbstractBackgroundMethylenetetrahydrofolate dehydrogenase (MTHFD1) catalyzes three sequential reacti...
Background: In recent years, the interest in genetic predisposition studies for coronary artery dise...
AbstractObjectives. We sought to determine whether the C677T transition in the methylenetetrahydrofo...
Alterations in the enzymes involved in homocysteine (Hcy) metabolism or vitamin deficiency could pla...
Background: The C677T mutation in methylenetetrahydrofolate reductase (MTHFR) gene is one of the cau...
Background: The C677T mutation in methylenetetrahydrofolate reductase (MTHFR) gene is one of the cau...
Elevated plasma total homocysteine (hcy), a risk factor for Coronary Artery Disease (CAD), is due to...