BACKGROUND:ZK 200775 is an antagonist at the alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor and had earned attention as a possible neuroprotective agent in cerebral ischemia. Probands receiving the agent within phase I trials reported on an alteration of visual perception. In this trial, the effects of ZK 200775 on the visual system were analyzed in detail. METHODOLOGY:In a randomised controlled trial we examined eyes and vision before and after the intravenous administration of two different doses of ZK 200775 and placebo. There were 3 groups of 6 probands each: Group 1 recieved 0.03 mg/kg/h, group 2 0.75 mg/kg/h of ZK 200775, the control group received 0.9% sodium chloride solution. Probands were healthy males aged b...
International audiencePURPOSE: To evaluate the effects on vision in patients receiving lamotrigine (...
The proof-of-concept (PoC) study described here examined the efficacy of BGG492 in a human model of ...
Background: Ethambutol is an antimicrobial agent used frequently to treat tuberculosis. The most com...
ZK 200775 is an antagonist at the α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor a...
Background and Purpose: ZK 200775 is a selective competitive AMPA receptor antagonist. It has demons...
Background and Purpose: ZK 200775 is a selective competitive AMPA receptor antagonist. It has demons...
Gernot Roessler, Michael Vobig, Peter Walter, Babac AE Mazinani Department of Ophthalmology, RWTH A...
Rationale: Drugs that enhance alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropanoic acid (AMPA) recept...
The generation of gamma-band (>30 Hz) cortical activity is thought to depend on the reciprocal conne...
The authors certify that all research involving human subjects was done under full compliance with a...
The effects of cholinergic agents undergoing clinical trials for the treatment of Alzheimer's diseas...
The principal aim of this work was to examine the effects of antiepileptic drugs (AEDs) on vision. V...
International audienceBACKGROUND: Previous studies have shown an effect of the tranquilizer lorazepa...
SummaryPurpose:To investigate whether initial valproate (VPA) monotherapy for the treatment of epile...
CB-5083 is an inhibitor of p97/valosin-containing protein (VCP), for which phase I trials for cancer...
International audiencePURPOSE: To evaluate the effects on vision in patients receiving lamotrigine (...
The proof-of-concept (PoC) study described here examined the efficacy of BGG492 in a human model of ...
Background: Ethambutol is an antimicrobial agent used frequently to treat tuberculosis. The most com...
ZK 200775 is an antagonist at the α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor a...
Background and Purpose: ZK 200775 is a selective competitive AMPA receptor antagonist. It has demons...
Background and Purpose: ZK 200775 is a selective competitive AMPA receptor antagonist. It has demons...
Gernot Roessler, Michael Vobig, Peter Walter, Babac AE Mazinani Department of Ophthalmology, RWTH A...
Rationale: Drugs that enhance alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropanoic acid (AMPA) recept...
The generation of gamma-band (>30 Hz) cortical activity is thought to depend on the reciprocal conne...
The authors certify that all research involving human subjects was done under full compliance with a...
The effects of cholinergic agents undergoing clinical trials for the treatment of Alzheimer's diseas...
The principal aim of this work was to examine the effects of antiepileptic drugs (AEDs) on vision. V...
International audienceBACKGROUND: Previous studies have shown an effect of the tranquilizer lorazepa...
SummaryPurpose:To investigate whether initial valproate (VPA) monotherapy for the treatment of epile...
CB-5083 is an inhibitor of p97/valosin-containing protein (VCP), for which phase I trials for cancer...
International audiencePURPOSE: To evaluate the effects on vision in patients receiving lamotrigine (...
The proof-of-concept (PoC) study described here examined the efficacy of BGG492 in a human model of ...
Background: Ethambutol is an antimicrobial agent used frequently to treat tuberculosis. The most com...