Hsa-miR-499 rs3746444 polymorphism contributes to cancer risk: a meta-analysis of 12 studies.

BACKGROUND: Single nucleotide polymorphisms (SNPs) occurred in pre-microRNAs or targets of microRNAs (miRs) may contribute to cancer risks. Since 2007, many studies have investigated the association between common SNPs located on hsa-miR-499 (rs3746444) and cancer risks; however, the results were inconclusive. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a meta-analysis of 12 studies that included 5765 cases and 7076 controls to identify the strength of association. Odds ratio (OR) and 95% confidence intervals (95% CI) were used to assess the strength of association. Overall, individuals with the variant AG (OR = 1.215, 95% CI: 1.027, 1.437; P(heterogeneity)<0.01) and AG/GG (OR = 1.227, 95% CI: 1.046, 1.439; P(heterogeneity)