STUDIES ON THE EFFECTS OF CYCLODEXTRIN POLYMER AS A TABLETING AID ON SOME SELECTED ANALGECICS

The clinical effectiveness of tablets and other pharmaceutical dosage forms of drug depends on at least two factors: the medication must not only be present in labeled amount but also must be available to the body. The drug availability is usually determined by the rate of release of drug from the dosage form. Such processes as the disintegration and dissolution of the drug govern the release of the drug from the tablet.\ud \ud In the present investigation, the effect of β-cyclodextrin on disintegration and the rate of dissolution of analgesic tablets (paracetamol and mefenamic acid) has been studied. The tablets were tested for the uniformity of weight, thickness and diameter, content of active ingredients, hardness, friability, disintegration time and rate of dissolution of drug. Three different sets were used for each drug.\ud \ud The best results were achieved from the formulation No.3 of both paracetamol and mefenamic acid formulations. The results were then compared with the commercially available tablets of each drug