25-Hydroxyvitamin D depletion does not exacerbate MPTP-induced dopamine neuron damage in mice.
- E Danielle Dean
- Lydia M Mexas
- Natalie L Cápiro
- Jeanne E McKeon
- Mahlon R DeLong
- Kurt D Pennell
- Jonathan A Doorn
- Vin Tangpricha
- Gary W Miller
- Marian L Evatt
DOIAbstract
Recent clinical evidence supports a link between 25-hydroxyvitamin D insufficiency (serum 25-hydroxyvitamin D [25(OH)D] levels <30 ng/mL) and Parkinson's disease. To investigate the effect of 25(OH)D depletion on neuronal susceptibility to toxic insult, we induced a state of 25(OH)D deficiency in mice and then challenged them with the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). We found there was no significant difference between control and 25(OH)D-deficient animals in striatal dopamine levels or dopamine transporter and tyrosine hydroxylase expression after lesioning with MPTP. Additionally, we found no difference in tyrosine hydroxylase expression in the substantia nigra pars compacta. Our data suggest th...
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