Low Dosage Ingestion of Chlorpyrifos Methyl Exposes to Acute Pancreatitis and Multiple Organ Failure: Role of Alpha Amylase

The Chlorpyrifos-methyl belongs to the organophosphorus pesticides, widely used in agriculture and for domestic gardening in several European countries. Its toxic action is associated with the inhibition of the enzyme acetylcholinesterase, which controls the levels of acetylcholine. Acute pancreatitis and hyperamylasemia are both possible consequence to a severe intoxication by Chlorpyrifos-methyl, however few cases are reported in the literature and they reported intoxication by high dosage of pesticide. In this case report, we suggest that even a slight dosage of pure Chlorpyrifos-methyl can cause pancreatic damage with the concrete risk of pump failure condition and multi-organs failure related to the processes of cytopathic hypoxia and of cellular oxidative stress. Finally, a prognostic role is proposed to the alpha-amylase, to evaluate the effectiveness of the pharmacological therap