To analyze the impact of the 11q deleted (11q-) cells in CLL patients on the time to first therapy (TFT) and overall survival (OS), 2,493 patients with CLL were studied. 242 patients (9.7%) had 11q-. Fluorescence in situ hybridization (FISH) studies showed a threshold of 40% of deleted cells to be optimal for showing that clinical differences in terms of TFT and OS within 11q- CLLs. In patients with ≥40% of losses in 11q (11q-H) (74%), the median TFT was 19 months compared with 44 months in CLL patients with <40% del(11q) (11q-L) (P<0.0001). In the multivariate analysis, only the presence of 11q-L, mutated IGHV status, early Binet stage and absence of extended lymphadenopathy were associated with longer TFT. Patients with 11q-H had an OS of...
Background: Chronic lymphocytic leukemia(CLL) is a monoclonal malignancy characterized by an accumul...
Deletion at 13q14 is detected by fluorescence in situ hybridization (FISH) in about 50% of chronic l...
This study revisited the Dohner prognostic hierarchy in a cohort of 1585 well-documented patients wi...
<div><p>To analyze the impact of the 11q deleted (11q-) cells in CLL patients on the time to first t...
To analyze the impact of the 11q deleted (11q-) cells in CLL patients on the time to first therapy (...
This is an open access article distributed under the terms of the Creative Commons Attribution Licen...
Deletion on the long arm of chromosome 11 occurs in 5-20% of chronic lymphocytic leukaemia (CLL) pat...
Abstract Deletion on the long arm of chromosome 11 occurs in 5-20% of chronic lymphocytic leuka...
BACKGROUND AND OBJECTIVES: Chromosome 11q22.3-23.1 deletions involving the ataxia-teleangiectasia mu...
Chromosomal abnormalities in chronic lymphocytic leukemia (CLL) are detected in up to 80% of patient...
Grupo Español de Leucemia Linfática Crónica (GELLC): et al.Deletion of 13q14 as the sole abnormality...
The clinical course of chronic lymphocytic leukemia (CLL) is extremely heterogeneous and while some ...
To better define the significance of clonal evolution (CE) including 14q32 translocations involving ...
Advances in molecular genetics during the last decade has made it possible to identify genetic lesio...
Up to 80% of Chronic Lymphocytic Leukemia (CLL) harbour clonal chromosome aberrations having importa...
Background: Chronic lymphocytic leukemia(CLL) is a monoclonal malignancy characterized by an accumul...
Deletion at 13q14 is detected by fluorescence in situ hybridization (FISH) in about 50% of chronic l...
This study revisited the Dohner prognostic hierarchy in a cohort of 1585 well-documented patients wi...
<div><p>To analyze the impact of the 11q deleted (11q-) cells in CLL patients on the time to first t...
To analyze the impact of the 11q deleted (11q-) cells in CLL patients on the time to first therapy (...
This is an open access article distributed under the terms of the Creative Commons Attribution Licen...
Deletion on the long arm of chromosome 11 occurs in 5-20% of chronic lymphocytic leukaemia (CLL) pat...
Abstract Deletion on the long arm of chromosome 11 occurs in 5-20% of chronic lymphocytic leuka...
BACKGROUND AND OBJECTIVES: Chromosome 11q22.3-23.1 deletions involving the ataxia-teleangiectasia mu...
Chromosomal abnormalities in chronic lymphocytic leukemia (CLL) are detected in up to 80% of patient...
Grupo Español de Leucemia Linfática Crónica (GELLC): et al.Deletion of 13q14 as the sole abnormality...
The clinical course of chronic lymphocytic leukemia (CLL) is extremely heterogeneous and while some ...
To better define the significance of clonal evolution (CE) including 14q32 translocations involving ...
Advances in molecular genetics during the last decade has made it possible to identify genetic lesio...
Up to 80% of Chronic Lymphocytic Leukemia (CLL) harbour clonal chromosome aberrations having importa...
Background: Chronic lymphocytic leukemia(CLL) is a monoclonal malignancy characterized by an accumul...
Deletion at 13q14 is detected by fluorescence in situ hybridization (FISH) in about 50% of chronic l...
This study revisited the Dohner prognostic hierarchy in a cohort of 1585 well-documented patients wi...