Prediction of week 4 virological response in hepatitis C for making decision on triple therapy: the Optim study.
- Manuel Romero-Gómez
- Juan Turnes
- Javier Ampuero
- Itziar Oyagüez
- Beatriz Cuenca
- Juan Gonzalez-Garcia
- Belén Muñoz-Molina
- Rocio Aguilar
- Sandra Leal
- Ramon Planas
- Javier Garcia-Samaniego
- Moises Diago
- Javier Crespo
- Jose Luis Calleja
- Miguel Angel Casado
- Ricard Sola
DOIAbstract
Virological response to peginterferon + ribavirin (P+R) at week 4 can predict sustained virological response (SVR). While patients with rapid virological response (RVR) do not require triple therapy, patients with a decline <1 log10 IU/ml HCVRNA (D1L) should have treatment discontinued due to low SVR rate.To develop a tool to predict first 4 weeks' viral response in patients with hepatitis C genotype 1&4 treated with P+R.In this prospective and multicenter study, HCV mono-infected (n=538) and HCV/HIV co-infected (n=186) patients were included. To develop and validate a prognostic tool to detect RVR and D1L, we segregated the patients as an estimation cohort (to construct the model) and a validation cohort (to validate the model).D1L was rea...
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