The Beneficial Effects of Renal Transplantation on Altered Oxidative Status of ESRD Patients

Renal transplantation (RT), has been considered the best therapeutic option for end stage renal disease (ESRD). Objective. To determine the effect of RT on the evolution of oxidative DNA status. Methods. Prospective cohort (N=50 receptors of RT); genotoxic damage, 8-hydroxy-2′-deoxyguanosine (8-OHdG), and DNA repair enzyme, human 8-oxoguanine-DNA-N- glycosylase-1 (hOGG1); and antioxidants, superoxide dismutase (SOD) and glutathione peroxidase (GPx), were evaluated. Results. Before RT, 8-OHdG were significantly elevated (11.04±0.90 versus 4.73 ± 0.34 ng/mL) compared to healthy controls (p=0.001), with normalization after 6 months of 4.78±0.34 ng/mL (p<0.001). The same phenomenon was observed with hOGG1 enzyme before RT with 2.14 ± 0.36 ng/mL (p=0.01) and decreased significantly at the end of the study to 1.20 ng/mL (p<0.001) but was higher than controls, 0.51 ± 0.07 ng/mL (p