Bacterial conjugation is the main mechanism for the dissemination of multiple antibiotic resistance in human pathogens. This dissemination could be controlled by molecules that interfere with the conjugation process. A search for conjugation inhibitors among a collection of 1,632 natural compounds, identified tanzawaic acids A and B as best hits. They specially inhibited IncW and IncFII conjugative systems, including plasmids mobilized by them. Plasmids belonging to IncFI, IncI, IncL/M, IncX and IncH incompatibility groups were targeted to a lesser extent, whereas IncN and IncP plasmids were unaffected. Tanzawaic acids showed reduced toxicity in bacterial, fungal or human cells, when compared to synthetic conjugation inhibitors, opening the...
Bacterial conjugation is the main mechanism for the transfer of multiple antimicrobial resistance ge...
Resumen del póster presentado al XXXVII Congreso de la Sociedad Española de Bioquímica y Biología Mo...
Horizontal transfer of antibiotic resistance genes carried by conjugative plasmids poses a serious h...
Bacterial conjugation is the main mechanism for the dissemination of multiple antibiotic resistance ...
Bacterial conjugation is the main mechanism for the dissemination of multiple antibiotic resistance ...
Bacterial conjugation constitutes a major horizontal gene transfer mechanism for the dissemination o...
Antibiotic resistance has become one of the most challenging problems in health care. Bacteria conju...
This report describes a high-throughput assay to identify substances that reduce the frequency of co...
ABSTRACT Plasmid conjugation is a major route for the spread of antibiotic resistance genes. Inhibit...
Antibiotic resistance has become one of the most challenging problems in health care. Bacteria conju...
Antibiotic resistance has become one of the most challenging problems in health care. Bacteria conju...
© 2021 Palencia-Gándara et al.Plasmid conjugation is a major route for the spread of antibiotic resi...
PMCID: PMC4908816Bacterial conjugation is the main mechanism responsible for the dissemination of an...
Bacterial conjugation is the main mechanism for the transfer of multiple antibiotic resistance genes...
Infections due to antibiotic-resistant (AbR) bacteria are a major cause of morbidity and mortality t...
Bacterial conjugation is the main mechanism for the transfer of multiple antimicrobial resistance ge...
Resumen del póster presentado al XXXVII Congreso de la Sociedad Española de Bioquímica y Biología Mo...
Horizontal transfer of antibiotic resistance genes carried by conjugative plasmids poses a serious h...
Bacterial conjugation is the main mechanism for the dissemination of multiple antibiotic resistance ...
Bacterial conjugation is the main mechanism for the dissemination of multiple antibiotic resistance ...
Bacterial conjugation constitutes a major horizontal gene transfer mechanism for the dissemination o...
Antibiotic resistance has become one of the most challenging problems in health care. Bacteria conju...
This report describes a high-throughput assay to identify substances that reduce the frequency of co...
ABSTRACT Plasmid conjugation is a major route for the spread of antibiotic resistance genes. Inhibit...
Antibiotic resistance has become one of the most challenging problems in health care. Bacteria conju...
Antibiotic resistance has become one of the most challenging problems in health care. Bacteria conju...
© 2021 Palencia-Gándara et al.Plasmid conjugation is a major route for the spread of antibiotic resi...
PMCID: PMC4908816Bacterial conjugation is the main mechanism responsible for the dissemination of an...
Bacterial conjugation is the main mechanism for the transfer of multiple antibiotic resistance genes...
Infections due to antibiotic-resistant (AbR) bacteria are a major cause of morbidity and mortality t...
Bacterial conjugation is the main mechanism for the transfer of multiple antimicrobial resistance ge...
Resumen del póster presentado al XXXVII Congreso de la Sociedad Española de Bioquímica y Biología Mo...
Horizontal transfer of antibiotic resistance genes carried by conjugative plasmids poses a serious h...