Human DICER1 protein cleaves double-stranded RNA into small sizes, a crucial step in production of single-stranded RNAs which are mediating factors of cytoplasmic RNA interference. Here, we clearly demonstrate that human DICER1 protein localizes not only to the cytoplasm but also to the nucleoplasm. We also find that human DICER1 protein associates with the NUP153 protein, one component of the nuclear pore complex. This association is detected predominantly in the cytoplasm but is also clearly distinguishable at the nuclear periphery. Additional characterization of the NUP153-DICER1 association suggests NUP153 plays a crucial role in the nuclear localization of the DICER1 protein
RNA silencing is a common term for pathways utilizing small RNAs as sequence-specific guides to repr...
The conserved ribonuclease Dicer generates microRNAs and short-interfering RNAs that guide gene sile...
SummaryThe endoribonuclease Dicer is known for its central role in the biogenesis of eukaryotic smal...
Dicer is a key player in microRNA (miRNA) and RNA interference (RNAi) pathways, processing miRNA pre...
Dicer is a central enzymatic player in RNA interference (RNAi) pathways that acts to regulate gene e...
Dicer is a central enzymatic player in RNA-interference pathways that acts to regulate gene expressi...
Dicer is a key component of RNA interference (RNAi) and well-known for its role in biogenesis of mic...
The endoribonuclease Dicer is a key component of the human RNA interference pathway and is known for...
Traffic between the nucleus and cytoplasm takes place through a macromolecular structure termed the ...
The vertebrate nuclear pore complex (NPC) is a macromolecular assembly of protein subcomplexes formi...
RNA silencing phenomena, known as post-transcrip-tional gene silencing in plants, quelling in fungi,...
SummaryRNAi is widely appreciated as a powerful regulator of mRNA translation in the cytoplasm of ma...
The ribonuclease Dicer plays a central role in the microRNA pathway by catalyzing the formation of m...
RNAi is widely appreciated as a powerful regulator of mRNA translation in the cytoplasm of mammalian...
RNAi is widely appreciated as a powerful regulator of mRNA translation in the cytoplasm of mammalian...
RNA silencing is a common term for pathways utilizing small RNAs as sequence-specific guides to repr...
The conserved ribonuclease Dicer generates microRNAs and short-interfering RNAs that guide gene sile...
SummaryThe endoribonuclease Dicer is known for its central role in the biogenesis of eukaryotic smal...
Dicer is a key player in microRNA (miRNA) and RNA interference (RNAi) pathways, processing miRNA pre...
Dicer is a central enzymatic player in RNA interference (RNAi) pathways that acts to regulate gene e...
Dicer is a central enzymatic player in RNA-interference pathways that acts to regulate gene expressi...
Dicer is a key component of RNA interference (RNAi) and well-known for its role in biogenesis of mic...
The endoribonuclease Dicer is a key component of the human RNA interference pathway and is known for...
Traffic between the nucleus and cytoplasm takes place through a macromolecular structure termed the ...
The vertebrate nuclear pore complex (NPC) is a macromolecular assembly of protein subcomplexes formi...
RNA silencing phenomena, known as post-transcrip-tional gene silencing in plants, quelling in fungi,...
SummaryRNAi is widely appreciated as a powerful regulator of mRNA translation in the cytoplasm of ma...
The ribonuclease Dicer plays a central role in the microRNA pathway by catalyzing the formation of m...
RNAi is widely appreciated as a powerful regulator of mRNA translation in the cytoplasm of mammalian...
RNAi is widely appreciated as a powerful regulator of mRNA translation in the cytoplasm of mammalian...
RNA silencing is a common term for pathways utilizing small RNAs as sequence-specific guides to repr...
The conserved ribonuclease Dicer generates microRNAs and short-interfering RNAs that guide gene sile...
SummaryThe endoribonuclease Dicer is known for its central role in the biogenesis of eukaryotic smal...