Background: CDC4/FBXW7, encoding a ubiquitin ligase, maps to 4q32 and has been implicated as a tumor suppressor gene and therapeutic target in many tumor types. Mutations in colonic adenomas, and the frequent losses on 4q described in gastric cancer prompt speculation about the role of CDC4/FBXW7 in gastric carcinogenesis
FBXW7 is the substrate recognition component of a SCF-type E3 ubiquitin ligase. It has multiple targ...
FBXW7 is the substrate recognition component of a SCF-type E3 ubiquitin ligase. It has multiple targ...
Aim - To investigate the role of DCC gene inactivation in the development and progression of gastric...
Background: CDC4/FBXW7, encoding a ubiquitin ligase, maps to 4q32 and has been implicated as a tumor...
Cancer is a leading cause of death worldwide. This somatic cell genetic disease is characterized by ...
FBXW7 (alias CDC4) is a p53-dependent tumor suppressor gene that exhibits mutations or deletions in ...
FBXW7 (alias CDC4) is a p53-dependent tumor suppressor gene that exhibits mutations or deletions in ...
BACKGROUND and AIMS: The E3 ubiquitin ligase F-box and WD repeat domain-containing 7 (Fbw7) degrades...
Abstract Background FBXW7, a component of the Skp-Cullin1-F-box, mediates target protein recognition...
The tumor suppressor FBW7 targets oncoproteins such as c-MYC for ubiquitylation and is mutated in se...
Abstract The ubiquitin-proteasome system (UPS) is involved in multiple aspects of cellular processes...
FBXW7 encodes the substrate recognition component of an SCF E3 ubiquitin ligase complex. This comple...
Gastric cancer is a major cause of global cancer mortality. We surveyed the spectrum of somatic alte...
Tumor suppressors with widespread impact on carcinogenesis control broad spectra of oncogenic pathwa...
Gastric cancer is constituted by two histomorphological entities ''intestinal'' and ''diffuse'' that...
FBXW7 is the substrate recognition component of a SCF-type E3 ubiquitin ligase. It has multiple targ...
FBXW7 is the substrate recognition component of a SCF-type E3 ubiquitin ligase. It has multiple targ...
Aim - To investigate the role of DCC gene inactivation in the development and progression of gastric...
Background: CDC4/FBXW7, encoding a ubiquitin ligase, maps to 4q32 and has been implicated as a tumor...
Cancer is a leading cause of death worldwide. This somatic cell genetic disease is characterized by ...
FBXW7 (alias CDC4) is a p53-dependent tumor suppressor gene that exhibits mutations or deletions in ...
FBXW7 (alias CDC4) is a p53-dependent tumor suppressor gene that exhibits mutations or deletions in ...
BACKGROUND and AIMS: The E3 ubiquitin ligase F-box and WD repeat domain-containing 7 (Fbw7) degrades...
Abstract Background FBXW7, a component of the Skp-Cullin1-F-box, mediates target protein recognition...
The tumor suppressor FBW7 targets oncoproteins such as c-MYC for ubiquitylation and is mutated in se...
Abstract The ubiquitin-proteasome system (UPS) is involved in multiple aspects of cellular processes...
FBXW7 encodes the substrate recognition component of an SCF E3 ubiquitin ligase complex. This comple...
Gastric cancer is a major cause of global cancer mortality. We surveyed the spectrum of somatic alte...
Tumor suppressors with widespread impact on carcinogenesis control broad spectra of oncogenic pathwa...
Gastric cancer is constituted by two histomorphological entities ''intestinal'' and ''diffuse'' that...
FBXW7 is the substrate recognition component of a SCF-type E3 ubiquitin ligase. It has multiple targ...
FBXW7 is the substrate recognition component of a SCF-type E3 ubiquitin ligase. It has multiple targ...
Aim - To investigate the role of DCC gene inactivation in the development and progression of gastric...
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