Wnt proteins are secreted molecules that play multiple roles during hair follicle development and postnatal hair cycling. Wntless (Wls) is a cargo protein required for the secretion of various Wnt ligands. However, its role during hair follicle development and hair cycling remains unclear. Here, we examined the expression of Wls during hair follicle induction and postnatal hair cycling. We also conditionally deleted Wls with K14-cre to investigate its role in hair follicle induction. K14-cre;Wls(c/c) mice exhibited abnormal hair follicle development, which is possibly caused by impaired canonical Wnt signaling. Meanwhile, Wnt5a is also expressed in embryonic epidermis, but Wnt5a null mice showed no significant defect in embryonic hair folli...
During embryonic and postnatal development, Wnt/beta-catenin signaling is involved in several stages...
Abstractβ-Catenin is an essential molecule in Wnt/wingless signaling, which controls decisive steps ...
Activation of β-catenin was shown to be of central importance for hair development and cycling. Rece...
Wnt proteins are secreted molecules that play multiple roles during hair follicle development and po...
A signal first arising in the dermis to initiate the development of hair follicles has been describe...
AbstractCharacterization of the molecular pathways controlling differentiation and proliferation in ...
β-Catenin, a key transducer molecule of Wnt signaling, is required for adult hair follicle growth an...
Embryonic hair follicle development and postnatal hair growth rely on intercellular communication wi...
<p>(A) Wls is expressed both in the surface ectoderm and underlying mesenchyme of the E13.5 embryo. ...
AbstractCharacterization of the molecular pathways controlling differentiation and proliferation in ...
A signal first arising in the dermis to initiate the development of hair follicles has been describe...
AbstractEctodermal appendage morphogenesis requires continuous epithelial–mesenchymal cross-talk dur...
AbstractBroad dermal Wnt signaling is required for patterned induction of hair follicle placodes and...
licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that th...
SummaryThe activity of keratinocytes in the hair follicle is regulated by signals from a specialized...
During embryonic and postnatal development, Wnt/beta-catenin signaling is involved in several stages...
Abstractβ-Catenin is an essential molecule in Wnt/wingless signaling, which controls decisive steps ...
Activation of β-catenin was shown to be of central importance for hair development and cycling. Rece...
Wnt proteins are secreted molecules that play multiple roles during hair follicle development and po...
A signal first arising in the dermis to initiate the development of hair follicles has been describe...
AbstractCharacterization of the molecular pathways controlling differentiation and proliferation in ...
β-Catenin, a key transducer molecule of Wnt signaling, is required for adult hair follicle growth an...
Embryonic hair follicle development and postnatal hair growth rely on intercellular communication wi...
<p>(A) Wls is expressed both in the surface ectoderm and underlying mesenchyme of the E13.5 embryo. ...
AbstractCharacterization of the molecular pathways controlling differentiation and proliferation in ...
A signal first arising in the dermis to initiate the development of hair follicles has been describe...
AbstractEctodermal appendage morphogenesis requires continuous epithelial–mesenchymal cross-talk dur...
AbstractBroad dermal Wnt signaling is required for patterned induction of hair follicle placodes and...
licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that th...
SummaryThe activity of keratinocytes in the hair follicle is regulated by signals from a specialized...
During embryonic and postnatal development, Wnt/beta-catenin signaling is involved in several stages...
Abstractβ-Catenin is an essential molecule in Wnt/wingless signaling, which controls decisive steps ...
Activation of β-catenin was shown to be of central importance for hair development and cycling. Rece...