Alpha-dystroglycan (alpha-DG) is a cell surface receptor providing a molecular link between the extracellular matrix (ECM) and the actin-based cytoskeleton. During its biosynthesis, alpha-DG undergoes specific and unusual O-glycosylation crucial for its function as a high-affinity cellular receptor for ECM proteins.We report that expression of functionally glycosylated alpha-DG during thymic development is tightly regulated in developing T cells and largely confined to CD4(-)CD8(-) double negative (DN) thymocytes. Ablation of DG in T cells had no effect on proliferation, migration or effector function but did reduce the size of the thymus due to a significant loss in absolute numbers of thymocytes. While numbers of DN thymocytes appeared no...
alpha-Dystroglycan (alpha-DG) was identified as a common receptor for lymphocytic choriomeningitis v...
The dystrophin associated protein (DAP) complex has been implicated in such basic physiological proc...
Glycosylation affects many essential T cell processes and is intrinsically controlled throughout the...
Background: Alpha-dystroglycan (a-DG) is a cell surface receptor providing a molecular link between ...
BACKGROUND: Alpha-dystroglycan (alpha-DG) is a cell surface receptor providing a molecular link betw...
The development of responsive and self-tolerant T cells is vital to immunity and autoimmunity and re...
Regulatory T-cells (Treg) are essential for maintaining immune homeostasis and tolerance. Surface gl...
Thymocyte development is accompanied by sequen-tial changes in cell surface glycosylation. For examp...
Regulatory T-cells (T-reg) play a pivotal role in maintaining immune homeostasis and tolerance. Ther...
The addition of sialic acid to O-linked glycans of the T-cell co-receptor CD8 is regulated during th...
Dystroglycan (DG) serves as an adhesion complex linking the actin cytoskeleton to the extracellular ...
During the intrathymic development, the fate of the thymocytes depends largely on variable expressio...
grantor: University of TorontoDuring thymic development, the TCR$\beta$-containing pre-TCR...
Posttranslational modification of alpha-dystroglycan (a-DG) by the like-acetylglucosaminyltransferas...
AbstractThe functional consequences of glycan structural changes associated with cellular differenti...
alpha-Dystroglycan (alpha-DG) was identified as a common receptor for lymphocytic choriomeningitis v...
The dystrophin associated protein (DAP) complex has been implicated in such basic physiological proc...
Glycosylation affects many essential T cell processes and is intrinsically controlled throughout the...
Background: Alpha-dystroglycan (a-DG) is a cell surface receptor providing a molecular link between ...
BACKGROUND: Alpha-dystroglycan (alpha-DG) is a cell surface receptor providing a molecular link betw...
The development of responsive and self-tolerant T cells is vital to immunity and autoimmunity and re...
Regulatory T-cells (Treg) are essential for maintaining immune homeostasis and tolerance. Surface gl...
Thymocyte development is accompanied by sequen-tial changes in cell surface glycosylation. For examp...
Regulatory T-cells (T-reg) play a pivotal role in maintaining immune homeostasis and tolerance. Ther...
The addition of sialic acid to O-linked glycans of the T-cell co-receptor CD8 is regulated during th...
Dystroglycan (DG) serves as an adhesion complex linking the actin cytoskeleton to the extracellular ...
During the intrathymic development, the fate of the thymocytes depends largely on variable expressio...
grantor: University of TorontoDuring thymic development, the TCR$\beta$-containing pre-TCR...
Posttranslational modification of alpha-dystroglycan (a-DG) by the like-acetylglucosaminyltransferas...
AbstractThe functional consequences of glycan structural changes associated with cellular differenti...
alpha-Dystroglycan (alpha-DG) was identified as a common receptor for lymphocytic choriomeningitis v...
The dystrophin associated protein (DAP) complex has been implicated in such basic physiological proc...
Glycosylation affects many essential T cell processes and is intrinsically controlled throughout the...