Lipopolysaccharide (LPS), a surface polymer of Gram-negative bacteria, helps bacteria survive in different environments and acts as a virulence determinant of host infection. The O-antigen (Oag) component of LPS exhibits a modal chain-length distribution that is controlled by polysaccharide co-polymerases (PCPs). The molecular basis of the regulation of Oag chain-lengths remains unclear, despite extensive mutagenesis and structural studies of PCPs from Escherichia coli and Shigella. Here, we identified a single mutation (A107P) of the Shigella flexneri WzzBSF, by a random mutagenesis approach, that causes a shortened Oag chain-length distribution in bacteria. We determined the crystal structures of the periplasmic domains of wild-type WzzBS...
Published Online: 01/04/2015The O antigen (Oag) component of lipopolysaccharide (LPS) is a major S. ...
The O antigen (Oag) component of lipopolysaccharides (LPS) is crucial for virulence and Oag chain-le...
It is shown that Shigella flexneri maintains genetic control over the modal chain length of the O-an...
Lipopolysaccharide (LPS), a surface polymer of Gram-negative bacteria, helps bacteria survive in dif...
<div><p>Lipopolysaccharide (LPS), a surface polymer of Gram-negative bacteria, helps bacteria surviv...
Lipopolysaccharide (LPS), a surface polymer of Gram-negative bacteria, helps bacteria sur-vive in di...
Lipopolysaccharide (LPS), a surface polymer of Gram-negative bacteria, helps bacteria survive in dif...
In Shigella flexneri, the polysaccharide copolymerase (PCP) protein WzzSF confers a modal length of ...
The surface O-antigen polymers of gram-negative bacteria exhibit a modal length distribution that de...
The O-antigen (Oag) component of lipopolysaccharide (LPS) is a major virulence determinant of Shigel...
Shigella flexneri can synthesize polysaccharide chains having complex sugars and a regulated number ...
The definitive version is available at www.blackwell-synergy.comThe lipopolysaccharide (LPS) molecul...
Outer membrane (OM) polysaccharides allow bacteria to resist harsh environmental conditions and anti...
The rfb region of Shigella flexneri encodes the proteins required to synthesize the O-antigen compon...
The O-antigen component of the lipopolysaccharide (LPS) represents a population of polysaccharide mo...
Published Online: 01/04/2015The O antigen (Oag) component of lipopolysaccharide (LPS) is a major S. ...
The O antigen (Oag) component of lipopolysaccharides (LPS) is crucial for virulence and Oag chain-le...
It is shown that Shigella flexneri maintains genetic control over the modal chain length of the O-an...
Lipopolysaccharide (LPS), a surface polymer of Gram-negative bacteria, helps bacteria survive in dif...
<div><p>Lipopolysaccharide (LPS), a surface polymer of Gram-negative bacteria, helps bacteria surviv...
Lipopolysaccharide (LPS), a surface polymer of Gram-negative bacteria, helps bacteria sur-vive in di...
Lipopolysaccharide (LPS), a surface polymer of Gram-negative bacteria, helps bacteria survive in dif...
In Shigella flexneri, the polysaccharide copolymerase (PCP) protein WzzSF confers a modal length of ...
The surface O-antigen polymers of gram-negative bacteria exhibit a modal length distribution that de...
The O-antigen (Oag) component of lipopolysaccharide (LPS) is a major virulence determinant of Shigel...
Shigella flexneri can synthesize polysaccharide chains having complex sugars and a regulated number ...
The definitive version is available at www.blackwell-synergy.comThe lipopolysaccharide (LPS) molecul...
Outer membrane (OM) polysaccharides allow bacteria to resist harsh environmental conditions and anti...
The rfb region of Shigella flexneri encodes the proteins required to synthesize the O-antigen compon...
The O-antigen component of the lipopolysaccharide (LPS) represents a population of polysaccharide mo...
Published Online: 01/04/2015The O antigen (Oag) component of lipopolysaccharide (LPS) is a major S. ...
The O antigen (Oag) component of lipopolysaccharides (LPS) is crucial for virulence and Oag chain-le...
It is shown that Shigella flexneri maintains genetic control over the modal chain length of the O-an...