TAZ expression as a prognostic indicator in colorectal cancer.
- Hiu-Fung Yuen
- Cian M McCrudden
- Yu-Han Huang
- Jill M Tham
- Xiaoqian Zhang
- Qi Zeng
- Shu-Dong Zhang
- WanJin Hong
DOIAbstract
The Hippo pathway restricts the activity of transcriptional coactivators TAZ (WWTR1) and YAP. TAZ and YAP are reported to be overexpressed in various cancers, however, their prognostic significance in colorectal cancers remains unstudied. The expression levels of TAZ and YAP, and their downstream transcriptional targets, AXL and CTGF, were extracted from two independent colon cancer patient datasets available in the Gene Expression Omnibus database, totaling 522 patients. We found that mRNA expressions of both TAZ and YAP were positively correlated with those of AXL and CTGF (p<0.05). High level mRNA expression of TAZ, AXL or CTGF significantly correlated with shorter survival. Importantly, patients co-overexpressing all 3 genes had a signi...
Add to ORKG