Recent pre-clinical studies have shown that complement activation contributes to glomerular and tubular injury in experimental FSGS. Although complement proteins are detected in the glomeruli of some patients with FSGS, it is not known whether this is due to complement activation or whether the proteins are simply trapped in sclerotic glomeruli. We measured complement activation fragments in the plasma and urine of patients with primary FSGS to determine whether complement activation is part of the disease process.Plasma and urine samples from patients with biopsy-proven FSGS who participated in the FSGS Clinical Trial were analyzed.We identified 19 patients for whom samples were available from weeks 0, 26, 52 and 78. The results for these ...
Glomerular deposition of complement-control proteins in acute and chronic glomerulonephritis. Acute ...
Classical pathway of complement activation in normal and diseased human glomeruli. Monoclonal antibo...
Complement activation in IgA nephropathy. Activation of alternative complement pathway is presumed t...
Recent pre-clinical studies have shown that complement activation contributes to glomerular and tubu...
Background Recent pre-clinical studies have shown that complement activation contributes to glomeru-...
BackgroundStudies on adriamycin mice model suggest complement system is activated and together with ...
<p>Ba, Bb, C4a, and sC5b-9 fragments were measured in the (A) plasma and (B) urine of FSGS patients ...
Purpose Linear or granular deposition of complement 3 (C3) along glomerular basement membrane (GBM) ...
Linear deposition of IgG and complement 3 (C3) along glomerular basement membrane (GBM) is generally...
Linear deposition of IgG and complement 3 (C3) along glomerular basement membrane (GBM) is generally...
INTRODUCTION: Complement-mediated tubular injury may play an important role in the progression of re...
Background and objectivesPrevious study revealed that complement activation products of the alternat...
sies studied by immunofluorescence contained varying combinations of immunoglobulins (Ig), complemen...
Deregulation or excessive activation of the complement system is now considered a fundamental aspect...
Abstract: Defective complement activation has been associated with various types of kidney disease. ...
Glomerular deposition of complement-control proteins in acute and chronic glomerulonephritis. Acute ...
Classical pathway of complement activation in normal and diseased human glomeruli. Monoclonal antibo...
Complement activation in IgA nephropathy. Activation of alternative complement pathway is presumed t...
Recent pre-clinical studies have shown that complement activation contributes to glomerular and tubu...
Background Recent pre-clinical studies have shown that complement activation contributes to glomeru-...
BackgroundStudies on adriamycin mice model suggest complement system is activated and together with ...
<p>Ba, Bb, C4a, and sC5b-9 fragments were measured in the (A) plasma and (B) urine of FSGS patients ...
Purpose Linear or granular deposition of complement 3 (C3) along glomerular basement membrane (GBM) ...
Linear deposition of IgG and complement 3 (C3) along glomerular basement membrane (GBM) is generally...
Linear deposition of IgG and complement 3 (C3) along glomerular basement membrane (GBM) is generally...
INTRODUCTION: Complement-mediated tubular injury may play an important role in the progression of re...
Background and objectivesPrevious study revealed that complement activation products of the alternat...
sies studied by immunofluorescence contained varying combinations of immunoglobulins (Ig), complemen...
Deregulation or excessive activation of the complement system is now considered a fundamental aspect...
Abstract: Defective complement activation has been associated with various types of kidney disease. ...
Glomerular deposition of complement-control proteins in acute and chronic glomerulonephritis. Acute ...
Classical pathway of complement activation in normal and diseased human glomeruli. Monoclonal antibo...
Complement activation in IgA nephropathy. Activation of alternative complement pathway is presumed t...