Peginesatide is an erythropoiesis stimulating agent (ESA) being developed for the treatment of anemia due to chronic kidney disease in dialysis patients. The purpose of this analysis was to develop a population PK-PD model to characterize time-course of peginesatide plasma and hemoglobin (Hb) concentrations following administration of IV and SC peginesatide injections. This population PK–PD analysis included 4 phase 2 studies and 1 phase 3 study. Baseline subject demographics, laboratory values, and concomitant medications were evaluated as covariates in a stepwise manner. Models were evaluated for goodness-of-fit using diagnostic plots, predictability based on visual predictive check, and stability based on bootstrap analyses. The final PK...
Peginesatide (P) is a synthetic, pegylated, peptide-based ESA approved for treatment of anemia due t...
BACKGROUND: Peginesatide, a synthetic peptide-based erythropoiesis- stimulating agent (ESA), is a po...
Neutropenia and febrile neutropenia (FN) are serious side effects of cytotoxic chemotherapy which ma...
Peginesatide is an erythropoiesis stimulating agent (ESA) being developed for the treatment of anemi...
Peginesatide (OMONTYS®) is an erythropoiesis-stimulating agent that was indicated in the United Stat...
Abstract Background Peginesatide is a peptide-based erythropoiesis-stimulating agent that was design...
<p>Upper panel: effect of PK covariates on simulated peginesatide plasma concentrations; Middle and ...
Ashraf MikhailRenal Unit, Morriston Hospital, Swansea University, Wales, UKAbstract: Peginesatide is...
BACKGROUND: Peginesatide is a peptide-based erythropoiesis-stimulating agent (ESA) that may have the...
Post hoc analysis of two Phase 3 pivotal trials (EMERALD 1,2) of peginesatide vs epoetin for anemia ...
Peginesatide, a synthetic peptide-based erythropoiesis-stimulating agent (ESA), is a potential thera...
The aim of the study was to describe the population pharmacokinetics (PK) of meropenem in critically...
<p>Upper left (2A): measured concentration versus predicted concentration; Upper middle (2B): measur...
stimulating agent (ESA) that is designed to specifically stimulate the erythropoietin receptor. This...
Anemia commonly occurs in people with chronic kidney disease (CKD) and is associated with poor clini...
Peginesatide (P) is a synthetic, pegylated, peptide-based ESA approved for treatment of anemia due t...
BACKGROUND: Peginesatide, a synthetic peptide-based erythropoiesis- stimulating agent (ESA), is a po...
Neutropenia and febrile neutropenia (FN) are serious side effects of cytotoxic chemotherapy which ma...
Peginesatide is an erythropoiesis stimulating agent (ESA) being developed for the treatment of anemi...
Peginesatide (OMONTYS®) is an erythropoiesis-stimulating agent that was indicated in the United Stat...
Abstract Background Peginesatide is a peptide-based erythropoiesis-stimulating agent that was design...
<p>Upper panel: effect of PK covariates on simulated peginesatide plasma concentrations; Middle and ...
Ashraf MikhailRenal Unit, Morriston Hospital, Swansea University, Wales, UKAbstract: Peginesatide is...
BACKGROUND: Peginesatide is a peptide-based erythropoiesis-stimulating agent (ESA) that may have the...
Post hoc analysis of two Phase 3 pivotal trials (EMERALD 1,2) of peginesatide vs epoetin for anemia ...
Peginesatide, a synthetic peptide-based erythropoiesis-stimulating agent (ESA), is a potential thera...
The aim of the study was to describe the population pharmacokinetics (PK) of meropenem in critically...
<p>Upper left (2A): measured concentration versus predicted concentration; Upper middle (2B): measur...
stimulating agent (ESA) that is designed to specifically stimulate the erythropoietin receptor. This...
Anemia commonly occurs in people with chronic kidney disease (CKD) and is associated with poor clini...
Peginesatide (P) is a synthetic, pegylated, peptide-based ESA approved for treatment of anemia due t...
BACKGROUND: Peginesatide, a synthetic peptide-based erythropoiesis- stimulating agent (ESA), is a po...
Neutropenia and febrile neutropenia (FN) are serious side effects of cytotoxic chemotherapy which ma...