Intercalated disk (ID), which electromechanically couples cardiomyocytes into a functional syncitium, is closely related to normal morphology and function of engineered heart tissues (EHTs), but the development mode of ID in the three-dimensional (3D) EHTs is still unclear. In this study, we focused on the spatiotemporal development of the ID in the EHTs constructed by mixing neonatal rat cardiomyocytes with collagen/Matrigel, and investigated the effect of 3D microenvironment provided by collagen/Matrigel matrix on the formation of ID. By histological and immmunofluorescent staining, the spatiotemporal distribution of ID-related junctions was detected. Furthermore, the ultra-structures of the ID in different developmental stages were obser...
AbstractCardiomyocytes are characterized by an extremely well-organized cytoarchitecture. We investi...
Patients with heart failure have, in spite of improved palliative therapies, bad prognosis. Cardiac ...
Engineered heart tissue (EHT) has ample potential as a model for in vitro tissue modeling or tissue ...
Background: In cardiac muscle, the intercalated disk (ID) at the longitudinal cell-edges of cardiomy...
In cardiac muscle, the intercalated disk (ID) at the longitudinal cell-edges of cardiomyocytes provi...
The intercalated disc (ID) contains different kinds of intercellular junctions: gap junctions (GJs),...
<p>Representative images of the immunostained cells within the tissue constructs. This series of ima...
AbstractThe intercalated disc (ICD) orchestrates electrochemical and mechanical communication betwee...
For electromechanical coupling of cardiomyocytes, intercalated discs (ICDs) are pivotal as highly sp...
Electrotonic coupling of cardiac myocytes at gap junctions may influence patterns of conduction in m...
Background—Cardiomyocyte transplantation is an innovative strategy for the treatment of heart failur...
Intercalated disks (ID) are specialized areas of cardiomyocytes membranes which serve to serially bi...
This review presents an extensively integrated model of the cardiac intercalated disc (ID), a highly...
This review presents an extensively integrated model of the cardiac intercalated disc (ID), a highly...
Patients with heart failure have, in spite of improved palliative therapies, bad prognosis. Cardiac ...
AbstractCardiomyocytes are characterized by an extremely well-organized cytoarchitecture. We investi...
Patients with heart failure have, in spite of improved palliative therapies, bad prognosis. Cardiac ...
Engineered heart tissue (EHT) has ample potential as a model for in vitro tissue modeling or tissue ...
Background: In cardiac muscle, the intercalated disk (ID) at the longitudinal cell-edges of cardiomy...
In cardiac muscle, the intercalated disk (ID) at the longitudinal cell-edges of cardiomyocytes provi...
The intercalated disc (ID) contains different kinds of intercellular junctions: gap junctions (GJs),...
<p>Representative images of the immunostained cells within the tissue constructs. This series of ima...
AbstractThe intercalated disc (ICD) orchestrates electrochemical and mechanical communication betwee...
For electromechanical coupling of cardiomyocytes, intercalated discs (ICDs) are pivotal as highly sp...
Electrotonic coupling of cardiac myocytes at gap junctions may influence patterns of conduction in m...
Background—Cardiomyocyte transplantation is an innovative strategy for the treatment of heart failur...
Intercalated disks (ID) are specialized areas of cardiomyocytes membranes which serve to serially bi...
This review presents an extensively integrated model of the cardiac intercalated disc (ID), a highly...
This review presents an extensively integrated model of the cardiac intercalated disc (ID), a highly...
Patients with heart failure have, in spite of improved palliative therapies, bad prognosis. Cardiac ...
AbstractCardiomyocytes are characterized by an extremely well-organized cytoarchitecture. We investi...
Patients with heart failure have, in spite of improved palliative therapies, bad prognosis. Cardiac ...
Engineered heart tissue (EHT) has ample potential as a model for in vitro tissue modeling or tissue ...