MGMT Leu84Phe polymorphism contributes to cancer susceptibility: evidence from 44 case-control studies.
- Jun Liu
- Renxia Zhang
- Fei Chen
- Cuicui Yu
- Yan Sun
- Chuanliang Jia
- Lijing Zhang
- Taufiq Salahuddin
- Xiaodong Li
- Juntian Lang
- Xicheng Song
DOIAbstract
BACKGROUND: O(6)-methylguanine-DNA methyltransferase is one of the few proteins to directly remove alkylating agents in the human DNA direct reversal repair pathway. A large number of case-control studies have been conducted to explore the association between MGMT Leu84Phe polymorphism and cancer risk. However, the results were not consistent. METHODS: We carried out a meta-analysis of 44 case-control studies to clarify the association between the Leu84Phe polymorphism and cancer risk. RESULTS: Overall, significant association of the T allele with cancer susceptibility was verified with meta-analysis under a recessive genetic model (P<0.001, OR=1.30, 95%CI 1.24-1.50) and TT versus CC comparison (P=0.001, OR=1.29, 95% CI 1.12-1.50). In subgr...
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