BACKGROUND: Clostridium difficile is an anaerobic, Gram-positive bacterium that has been implicated as the leading cause of antibiotic-associated diarrhea. Metronidazole is currently the first-line treatment for mild to moderate C. difficile infections. Our laboratory isolated a strain of C. difficile with a stable resistance phenotype to metronidazole. A shotgun proteomics approach was used to compare differences in the proteomes of metronidazole-resistant and -susceptible isolates. METHODOLOGY/PRINCIPAL FINDINGS: NAP1 C. difficile strains CD26A54_R (Met-resistant), CD26A54_S (reduced- susceptibility), and VLOO13 (Met-susceptible) were grown to mid-log phase, and spiked with metronidazole at concentrations 2 doubling dilutions below the MI...
Clostridium difficile, a major cause of antibiotic-associated diarrhea, produces highly resistant sp...
Metronidazole (MTZ) is a clinically important antimicrobial agent that is active against both bacter...
Clostridium difficile is the leading cause of antibiotic-associated diarrhea in hospitals worldwide,...
Background: Clostridium difficile is an anaerobic, Gram-positive bacterium that has been implicated ...
<div><p>Background</p><p><i>Clostridium difficile</i> is an anaerobic, Gram-positive bacterium that ...
Clostridioides difficile is responsible for various intestinal symptoms from mild diarrhea to severe...
International audienceClostridioides difficile is responsible for various intestinal symptoms from m...
Stable resistance to metronidazole in a nontoxigenic Clostridium difficile strain was investigated a...
The anaerobic pathogen Clostridium difficile is of growing significance for the health care system d...
with a stable resistance phenotype to metronidazole. A shotgun proteomics approach was used to comp...
Background: Clostridium difficile are Gram-positive, spore forming anaerobic bacteria that are the l...
BACKGROUND: Clostridium difficile are gram-positive, spore forming anaerobic bacteria that are the l...
International audienceStable resistance to metronidazole in a nontoxigenic Clostridium difficile str...
Abstract Background Clostridium difficile is the causative agent of C. difficile infection (CDI) tha...
The recent increase in availability of next generation sequencing methodologies has led to extensive...
Clostridium difficile, a major cause of antibiotic-associated diarrhea, produces highly resistant sp...
Metronidazole (MTZ) is a clinically important antimicrobial agent that is active against both bacter...
Clostridium difficile is the leading cause of antibiotic-associated diarrhea in hospitals worldwide,...
Background: Clostridium difficile is an anaerobic, Gram-positive bacterium that has been implicated ...
<div><p>Background</p><p><i>Clostridium difficile</i> is an anaerobic, Gram-positive bacterium that ...
Clostridioides difficile is responsible for various intestinal symptoms from mild diarrhea to severe...
International audienceClostridioides difficile is responsible for various intestinal symptoms from m...
Stable resistance to metronidazole in a nontoxigenic Clostridium difficile strain was investigated a...
The anaerobic pathogen Clostridium difficile is of growing significance for the health care system d...
with a stable resistance phenotype to metronidazole. A shotgun proteomics approach was used to comp...
Background: Clostridium difficile are Gram-positive, spore forming anaerobic bacteria that are the l...
BACKGROUND: Clostridium difficile are gram-positive, spore forming anaerobic bacteria that are the l...
International audienceStable resistance to metronidazole in a nontoxigenic Clostridium difficile str...
Abstract Background Clostridium difficile is the causative agent of C. difficile infection (CDI) tha...
The recent increase in availability of next generation sequencing methodologies has led to extensive...
Clostridium difficile, a major cause of antibiotic-associated diarrhea, produces highly resistant sp...
Metronidazole (MTZ) is a clinically important antimicrobial agent that is active against both bacter...
Clostridium difficile is the leading cause of antibiotic-associated diarrhea in hospitals worldwide,...