Transcription factors are tools repetitively used by the embryo to generate a variety of lineages. Hence, their context of activation is an important determinant of their ability to specifically trigger certain cell fates, but not others. The context is also consequential when considering directing differentiation of embryonic stem cells (ESCs). In this study, we sought to assess the context of pancreatic transcription factor 1a (PTF1a) activation in reference to its propancreatic effects in mouse ESCs (mESCs). We hypothesized that an enriched endodermal population would respond to PTF1a and trigger the pancreatic program more effectively than a spontaneously differentiated population. Using an in vitro model of pancreas development that we...
The identification of the molecular mechanisms controlling early cell fate decisions in mammals is o...
AbstractThe pancreas is derived from a pool of multipotent progenitor cells (MPCs) that co-express P...
Understanding the tissue interactions that induce pancreatic progenitor cells from the embryonic end...
Protein transduction domains (PTDs), such as the HIV1-TAT peptide, have been previously used to prom...
<div><p>Protein transduction domains (PTDs), such as the HIV1-TAT peptide, have been previously used...
Islet transplantation has proven to be a successful strategy to restore normoglycemia in patients wi...
SummaryPluripotent embryonic cells become progressively lineage restricted during development in a p...
Pluripotent embryonic stem cells (ESC) are a promising cellular system for generating an unlimited s...
Pluripotent embryonic stem cells (ESC) are a promising cellular system for generating an unlimited s...
<div><p>Pluripotent embryonic stem cells (ESC) are a promising cellular system for generating an unl...
SummaryPluripotent embryonic cells become progressively lineage restricted during development in a p...
The identification of the molecular mechanisms controlling early cell fate decisions in mammals is o...
The identification of the molecular mechanisms controlling early cell fate decisions in mammals is o...
The identification of the molecular mechanisms controlling early cell fate decisions in mammals is o...
The identification of the molecular mechanisms controlling early cell fate decisions in mammals is o...
The identification of the molecular mechanisms controlling early cell fate decisions in mammals is o...
AbstractThe pancreas is derived from a pool of multipotent progenitor cells (MPCs) that co-express P...
Understanding the tissue interactions that induce pancreatic progenitor cells from the embryonic end...
Protein transduction domains (PTDs), such as the HIV1-TAT peptide, have been previously used to prom...
<div><p>Protein transduction domains (PTDs), such as the HIV1-TAT peptide, have been previously used...
Islet transplantation has proven to be a successful strategy to restore normoglycemia in patients wi...
SummaryPluripotent embryonic cells become progressively lineage restricted during development in a p...
Pluripotent embryonic stem cells (ESC) are a promising cellular system for generating an unlimited s...
Pluripotent embryonic stem cells (ESC) are a promising cellular system for generating an unlimited s...
<div><p>Pluripotent embryonic stem cells (ESC) are a promising cellular system for generating an unl...
SummaryPluripotent embryonic cells become progressively lineage restricted during development in a p...
The identification of the molecular mechanisms controlling early cell fate decisions in mammals is o...
The identification of the molecular mechanisms controlling early cell fate decisions in mammals is o...
The identification of the molecular mechanisms controlling early cell fate decisions in mammals is o...
The identification of the molecular mechanisms controlling early cell fate decisions in mammals is o...
The identification of the molecular mechanisms controlling early cell fate decisions in mammals is o...
AbstractThe pancreas is derived from a pool of multipotent progenitor cells (MPCs) that co-express P...
Understanding the tissue interactions that induce pancreatic progenitor cells from the embryonic end...