The L1 cell adhesion molecule promotes neurite outgrowth and neuronal survival in homophilic and heterophilic interactions and enhances neurite outgrowth and neuronal survival homophilically, i.e. by self binding. We investigated whether exploitation of homophilic and possibly also heterophilic mechanisms of neural stem cells overexpressing the full-length transmembrane L1 and a secreted trimer engineered to express its extracellular domain would be more beneficial for functional recovery of the compression injured spinal cord of adult mice than stem cells overexpressing only full-length L1 or the parental, non-engineered cells. Here we report that stem cells expressing trimeric and full-length L1 are indeed more efficient in promoting loco...
Previously we reported that neural stem cells (NSCs) embedded in fibrin matrices containing 9 growth...
Spinal muscular atrophy (SMA), characterized by selective loss of lower motor neurons, is an incurab...
Genetically modified mono-nuclear cell fraction from human umbilical cord blood (HUCB) expressing hu...
The L1 cell adhesion molecule promotes neurite outgrowth and neuronal survival in homophilic and het...
An obstacle to early stem cell transplantation into the acutely injured spinal cord is poor survival...
Embryonic stem cells are pluripotent cells that have the ability to differentiate into cell lineages...
The neural cell adhesion molecule (NCAM) plays important functional roles in development of the nerv...
Spinal cord injury (SCI) affects millions of individuals worldwide. Currently, there is no cure, and...
Spinal cord injury (SCI) affects millions of individuals worldwide. Currently, there is no cure, and...
Traumatic spinal cord injuries (SCIs) affect millions of people worldwide; the majority of whom are ...
Neural stem cells are emerging as a regenerative therapy for spinal cord injury (SCI), since they di...
The limited capability of regeneration in the human central nervous system leads to severe and perma...
Traumatic spinal cord injury results in persistent disability due to disconnection of surviving neur...
Genetically modified mono-nuclear cell fraction from human umbilical cord blood (HUCB) expressing hu...
Genetically modified mono-nuclear cell fraction from human umbilical cord blood (HUCB) expressing hu...
Previously we reported that neural stem cells (NSCs) embedded in fibrin matrices containing 9 growth...
Spinal muscular atrophy (SMA), characterized by selective loss of lower motor neurons, is an incurab...
Genetically modified mono-nuclear cell fraction from human umbilical cord blood (HUCB) expressing hu...
The L1 cell adhesion molecule promotes neurite outgrowth and neuronal survival in homophilic and het...
An obstacle to early stem cell transplantation into the acutely injured spinal cord is poor survival...
Embryonic stem cells are pluripotent cells that have the ability to differentiate into cell lineages...
The neural cell adhesion molecule (NCAM) plays important functional roles in development of the nerv...
Spinal cord injury (SCI) affects millions of individuals worldwide. Currently, there is no cure, and...
Spinal cord injury (SCI) affects millions of individuals worldwide. Currently, there is no cure, and...
Traumatic spinal cord injuries (SCIs) affect millions of people worldwide; the majority of whom are ...
Neural stem cells are emerging as a regenerative therapy for spinal cord injury (SCI), since they di...
The limited capability of regeneration in the human central nervous system leads to severe and perma...
Traumatic spinal cord injury results in persistent disability due to disconnection of surviving neur...
Genetically modified mono-nuclear cell fraction from human umbilical cord blood (HUCB) expressing hu...
Genetically modified mono-nuclear cell fraction from human umbilical cord blood (HUCB) expressing hu...
Previously we reported that neural stem cells (NSCs) embedded in fibrin matrices containing 9 growth...
Spinal muscular atrophy (SMA), characterized by selective loss of lower motor neurons, is an incurab...
Genetically modified mono-nuclear cell fraction from human umbilical cord blood (HUCB) expressing hu...