We demonstrate quantitatively that, as predicted by evolutionary theory, sequences of homologous proteins from different species converge as we go further and further back in time. The converse, a non-evolutionary model can be expressed as probabilities, and the test works for chloroplast, nuclear and mitochondrial sequences, as well as for sequences that diverged at different time depths. Even on our conservative test, the probability that chance could produce the observed levels of ancestral convergence for just one of the eight datasets of 51 proteins is ≈1×10⁻¹⁹ and combined over 8 datasets is ≈1×10⁻¹³². By comparison, there are about 10⁸⁰ protons in the universe, hence the probability that the sequences could have been produced by a pr...
Evolutionary studies usually assume that the genetic mutations are independent of each other. Howeve...
Most models of nucleotide or amino acid substitution used in phylogenetic studies assume that the ev...
This paper explores what would happen to a chromosomal segment that evolves randomly, without the su...
We demonstrate quantitatively that, as predicted by evolutionary theory, sequences of homologous pro...
Abstract Early studies of molecular evolution revealed a correlation between genetic distance and ti...
Convergence is a central concept in evolutionary studies because it provides strong evidence for ada...
The phylogenetic inference of ancestral protein sequences is a powerful technique for the study of m...
Protein sequence changes are a major contributor to phenotypic evolution and biodiversity. While the...
Although overwhelming circumstantial evidence supports the existence of the universal common ancesto...
A model for testing molecular evolution is proposed. Randomness of recurrent mutation is defined bas...
Evolution is presumed to proceed by random mutations, which increase an individual’s fitness. Increa...
The genesis of a structured and functional protein by random processes is exceedingly unlikely. Howe...
The topics of the article has been restricted to those, which seem to represent the most well-establ...
1 Modelling sequence change over time How have gene and protein sequences evolved overtime? Of the m...
Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, p...
Evolutionary studies usually assume that the genetic mutations are independent of each other. Howeve...
Most models of nucleotide or amino acid substitution used in phylogenetic studies assume that the ev...
This paper explores what would happen to a chromosomal segment that evolves randomly, without the su...
We demonstrate quantitatively that, as predicted by evolutionary theory, sequences of homologous pro...
Abstract Early studies of molecular evolution revealed a correlation between genetic distance and ti...
Convergence is a central concept in evolutionary studies because it provides strong evidence for ada...
The phylogenetic inference of ancestral protein sequences is a powerful technique for the study of m...
Protein sequence changes are a major contributor to phenotypic evolution and biodiversity. While the...
Although overwhelming circumstantial evidence supports the existence of the universal common ancesto...
A model for testing molecular evolution is proposed. Randomness of recurrent mutation is defined bas...
Evolution is presumed to proceed by random mutations, which increase an individual’s fitness. Increa...
The genesis of a structured and functional protein by random processes is exceedingly unlikely. Howe...
The topics of the article has been restricted to those, which seem to represent the most well-establ...
1 Modelling sequence change over time How have gene and protein sequences evolved overtime? Of the m...
Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, p...
Evolutionary studies usually assume that the genetic mutations are independent of each other. Howeve...
Most models of nucleotide or amino acid substitution used in phylogenetic studies assume that the ev...
This paper explores what would happen to a chromosomal segment that evolves randomly, without the su...