Add to ORKGColon cancer is a common disease that can be sporadic or familial. An inactivated adenomatous polyposis coli (APC) suppressor gene is found in over 80% of colorectal tumors, this being an early alteration in the development of adenomatous polyps. APC function is not only critical for tumor initiation and progression, and chromosome instability (CIN) is another characteristic dependent at least partly on APC mutations
Mutations in the APC gene give rise to familial adenomatous polyposis (FAP) and also occur in many, ...
In colorectal tumours, Wnt pathway genetics continues to be dominated by mutations in the adenomatou...
In colorectal tumours, Wnt pathway genetics continues to be dominated by mutations in the adenomatou...
Mutations in the adenomatous polyposis coli (APC) gene are the basis of familial adenomatous polypos...
The adenomatous polyposis coli (APC) gene has been shown to be involved in genetic instability and t...
Although APC mutations occur at a high frequency in colorectal cancers, few studies have performed a...
Colon cancer closely follows the paradigm of a single “gatekeeper gene. ” Mutations inactivating th...
In vitro data show that the adenomatous polyposis coli (APC) protein associates with the mitotic spi...
AbstractThe adenomatous polyposis coli (APC) tumor suppressor protein is inactivated by mutations in...
The adenomatous polyposis coli (APC) gene is considered to be a gatekeeper in colorectal tumourigene...
It is not clear whether APC mutations are sufficient for early colorectal adenomas to grow or whethe...
Colon cancer is the second most lethal cancer; approximately 600,000 people die of it annually in th...
Two forms of genetic instability have been described in colorectal cancer1: microsatellite instabili...
The roles of the intrinsic mutation rate and genomic instability in tumorigenesis are currently cont...
Two forms of genetic instability have been described in colorectal cancer1: microsatellite instabili...
Mutations in the APC gene give rise to familial adenomatous polyposis (FAP) and also occur in many, ...
In colorectal tumours, Wnt pathway genetics continues to be dominated by mutations in the adenomatou...
In colorectal tumours, Wnt pathway genetics continues to be dominated by mutations in the adenomatou...
Mutations in the adenomatous polyposis coli (APC) gene are the basis of familial adenomatous polypos...
The adenomatous polyposis coli (APC) gene has been shown to be involved in genetic instability and t...
Although APC mutations occur at a high frequency in colorectal cancers, few studies have performed a...
Colon cancer closely follows the paradigm of a single “gatekeeper gene. ” Mutations inactivating th...
In vitro data show that the adenomatous polyposis coli (APC) protein associates with the mitotic spi...
AbstractThe adenomatous polyposis coli (APC) tumor suppressor protein is inactivated by mutations in...
The adenomatous polyposis coli (APC) gene is considered to be a gatekeeper in colorectal tumourigene...
It is not clear whether APC mutations are sufficient for early colorectal adenomas to grow or whethe...
Colon cancer is the second most lethal cancer; approximately 600,000 people die of it annually in th...
Two forms of genetic instability have been described in colorectal cancer1: microsatellite instabili...
The roles of the intrinsic mutation rate and genomic instability in tumorigenesis are currently cont...
Two forms of genetic instability have been described in colorectal cancer1: microsatellite instabili...
Mutations in the APC gene give rise to familial adenomatous polyposis (FAP) and also occur in many, ...
In colorectal tumours, Wnt pathway genetics continues to be dominated by mutations in the adenomatou...
In colorectal tumours, Wnt pathway genetics continues to be dominated by mutations in the adenomatou...