Role of HLA-DP polymorphisms on chronicity and disease activity of hepatitis B infection in Southern Chinese.

Danny Ka-Ho Wong
Tsunamasa Watanabe
Yasuhito Tanaka
Wai-Kay Seto
Cheuk-Kwong Lee
James Fung
Che-Kit Lin
Fung-Yu Huang
Ching-Lung Lai
Man-Fung Yuen

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DOI

10.1371/journal.pone.0066920

Publisher

Public Library of Science (PLoS)

Journal

issn:1932-6203

Abstract

BACKGROUND AND AIMS: The association between HLA-DP single nucleotide polymorphisms (SNPs) and chronic hepatitis B virus (HBV) infection varies between different populations. We aimed to study the association between HLA-DP SNPs and HBV infection and disease activity in the Chinese population of Hong Kong. METHODS: We genotyped SNPs rs3077 (near HLA-DPA1) and rs9277378 and rs3128917 (both near HLA-DPB1) in 500 HBV carriers (hepatitis B surface antigen [HBsAg]-positive), 245 non-HBV infected controls (HBsAg- and antibody to hepatitis B core protein [anti-HBc]-negative), and 259 subjects with natural HBV clearance (HBsAg-negative, anti-HBc-positive). Inactive HBV carriers state was defined by HBV DNA levels <2,000 IU/ml and persistently norma...