Inflammation is a relevant factor in the pathogenesis of diabetes nephropathy (DN). Sesquiterpene lactones (SLs), originally isolated from Tanacetum parthenium, have been reported to exhibit anti-inflammatory effects but few studies have examined their effects on DN. To determine whether advanced oxidation protein products (AOPPs) can induce the expression of chemokine monocyte chemoattractant protein- (MCP-) 1 in cultured mouse podocytes and to explore the mechanisms of the potential renoprotection of SLs, we treated podocytes with AOPPs and SLs (parthenolide and its derivatives micheliolide, compound 1, and compound 2). MCP-1 mRNA and protein expression were tested using quantitative real-time PCR and ELISA, respectively, and the protein ...
Extracts from certain Mexican Indian medicinal plants used in traditional indigenous medicine for th...
Chronic kidney disease (CKD) is characterized by progressive decline in renal function. Podocyte dro...
Abstract Background Jiangtang decoction (JTD) is a China patented drug which contains Euphorbia humi...
Copyright © 2015 Yan Zhao et al.This is an open access article distributed under theCreative Commons...
Background: Monocyte chemoattractant protein-1 (MCP-1) plays an important role in extracellular matr...
Diabetic nephropathy (DN) is one of the most common and serious chronic complications of diabetes me...
Chronic kidney disease is a common disease closely related to renal tubular inflammation and oxidati...
The study aims to investigate the effects of the alcohol extract of Coreopsis tinctoria Nutt (AC) on...
Renal reactive oxygen species (ROS) and mononuclear leukocyte infiltration are involved in the progr...
Diabetes patients are more prone to acute kidney injury (AKI). Endopeptidases known as matrix metall...
Diabetic nephropathy (DN) is a leading cause of kidney morbidity. Despite the multilayered complexit...
Background. Podocyte injury plays an important role in diabetic nephropathy (DN). The aim of this st...
Macrophages accumulate in kidney glomeruli and interstitium of patients with diabetic nephropathy in...
Thioredoxin-interacting protein (TxNIP), an endogenous inhibitor of the thiol oxidoreductase - thior...
Expression of thioredoxin-interacting protein (TxNIP), an endogenous inhibitor of the thiol oxidored...
Extracts from certain Mexican Indian medicinal plants used in traditional indigenous medicine for th...
Chronic kidney disease (CKD) is characterized by progressive decline in renal function. Podocyte dro...
Abstract Background Jiangtang decoction (JTD) is a China patented drug which contains Euphorbia humi...
Copyright © 2015 Yan Zhao et al.This is an open access article distributed under theCreative Commons...
Background: Monocyte chemoattractant protein-1 (MCP-1) plays an important role in extracellular matr...
Diabetic nephropathy (DN) is one of the most common and serious chronic complications of diabetes me...
Chronic kidney disease is a common disease closely related to renal tubular inflammation and oxidati...
The study aims to investigate the effects of the alcohol extract of Coreopsis tinctoria Nutt (AC) on...
Renal reactive oxygen species (ROS) and mononuclear leukocyte infiltration are involved in the progr...
Diabetes patients are more prone to acute kidney injury (AKI). Endopeptidases known as matrix metall...
Diabetic nephropathy (DN) is a leading cause of kidney morbidity. Despite the multilayered complexit...
Background. Podocyte injury plays an important role in diabetic nephropathy (DN). The aim of this st...
Macrophages accumulate in kidney glomeruli and interstitium of patients with diabetic nephropathy in...
Thioredoxin-interacting protein (TxNIP), an endogenous inhibitor of the thiol oxidoreductase - thior...
Expression of thioredoxin-interacting protein (TxNIP), an endogenous inhibitor of the thiol oxidored...
Extracts from certain Mexican Indian medicinal plants used in traditional indigenous medicine for th...
Chronic kidney disease (CKD) is characterized by progressive decline in renal function. Podocyte dro...
Abstract Background Jiangtang decoction (JTD) is a China patented drug which contains Euphorbia humi...