Cadmium is a common toxicant that is detrimental to many tissues. Although a number of transcriptional signatures have been revealed in different tissues after cadmium treatment, the genes involved in the cadmium caused male reproductive toxicity, and the underlying molecular mechanism remains unclear. Here we observed that the mice treated with different amount of cadmium in their rodent chow for six months exhibited reduced serum testosterone. We then performed RNA-seq to comprehensively investigate the mice testicular transcriptome to further elucidate the mechanism. Our results showed that hundreds of genes expression altered significantly in response to cadmium treatment. In particular, we found several transcriptional signatures close...
Heavy metals polluting our environment cause concern for developing organisms. Among them, cadmium w...
Cadmium (Cd), a highly toxic pollutant, impairs oocyte fertilization, through oxidative damage on cu...
Cadmium is a metal known to be toxic and carcinogenic, but its mechanism of action remains to be ful...
which permits unrestricted use, distribution, and reproduction in any medium, provided the original ...
Sulforaphane (SFN) is a natural and highly effective antioxidant. Studies suggest that SFN protects ...
<p>Cadmium is a human carcinogen and a persistent environmental pollutant of increasing concern. Yet...
Cadmium is an environmental pollutant known as endocrine disruptor. Testis is particularly susceptib...
Exposure to low levels of cadmium reduces fertility. In male mice spermatogenesis is highly sensitiv...
Accumulation of the heavy metal Cadmium (Cd) in the ovaries and placenta can affect the structure an...
The control of gene expression occurs at multiple levels one of which is controlled by epigenetic re...
Apoptosis and a change in the expression of p53, c-jun and MT-I genes occurred in rats exposed to ca...
Cadmium (Cd) is one of the most toxic pollutants for health due to its accumulation in several tissu...
Cadmium is a metalloestrogen known to activate the estrogen receptor and promote breast cancer cell ...
Cadmium is a well recognized carcinogen, primarily released into the environment by anthropogenic ac...
Cadmium is a carcinogenic metal, the mechanisms of which are not fully understood. In this study, hu...
Heavy metals polluting our environment cause concern for developing organisms. Among them, cadmium w...
Cadmium (Cd), a highly toxic pollutant, impairs oocyte fertilization, through oxidative damage on cu...
Cadmium is a metal known to be toxic and carcinogenic, but its mechanism of action remains to be ful...
which permits unrestricted use, distribution, and reproduction in any medium, provided the original ...
Sulforaphane (SFN) is a natural and highly effective antioxidant. Studies suggest that SFN protects ...
<p>Cadmium is a human carcinogen and a persistent environmental pollutant of increasing concern. Yet...
Cadmium is an environmental pollutant known as endocrine disruptor. Testis is particularly susceptib...
Exposure to low levels of cadmium reduces fertility. In male mice spermatogenesis is highly sensitiv...
Accumulation of the heavy metal Cadmium (Cd) in the ovaries and placenta can affect the structure an...
The control of gene expression occurs at multiple levels one of which is controlled by epigenetic re...
Apoptosis and a change in the expression of p53, c-jun and MT-I genes occurred in rats exposed to ca...
Cadmium (Cd) is one of the most toxic pollutants for health due to its accumulation in several tissu...
Cadmium is a metalloestrogen known to activate the estrogen receptor and promote breast cancer cell ...
Cadmium is a well recognized carcinogen, primarily released into the environment by anthropogenic ac...
Cadmium is a carcinogenic metal, the mechanisms of which are not fully understood. In this study, hu...
Heavy metals polluting our environment cause concern for developing organisms. Among them, cadmium w...
Cadmium (Cd), a highly toxic pollutant, impairs oocyte fertilization, through oxidative damage on cu...
Cadmium is a metal known to be toxic and carcinogenic, but its mechanism of action remains to be ful...