Particulate matter exposure exacerbates high glucose-induced cardiomyocyte dysfunction through ROS generation.

Li Zuo
Dane J Youtz
Loren E Wold

Open link

DOI

10.1371/journal.pone.0023116

Publisher

Public Library of Science (PLoS)

Journal

issn:1932-6203

Abstract

Diabetes mellitus and fine particulate matter from diesel exhaust (DEP) are both important contributors to the development of cardiovascular disease (CVD). Diabetes mellitus is a progressive disease with a high mortality rate in patients suffering from CVD, resulting in diabetic cardiomyopathy. Elevated DEP levels in the air are attributed to the development of various CVDs, presumably since fine DEP (<2.5 µm in diameter) can be inhaled and gain access to the circulatory system. However, mechanisms defining how DEP affects diabetic or control cardiomyocyte function remain poorly understood. The purpose of the present study was to evaluate cardiomyocyte function and reactive oxygen species (ROS) generation in isolated rat ventricular myocyte...