Organic cation transporter 1 (OCT1, SLC22A1), like many solute carrier 22 (SLC22) family members, is important for the disposition of clinically important drugs, metabolites and signaling molecules. Several studies suggest that SLC22 family (eg. organic anion transporters or OATs and OCTs) bind and possibly transport prostaglandins with relatively high affinity (submicromolar). The affinities of OCT1 and OATs toward PGE2 and PGF2a reported in these cell-based transport studies are considerably greater than for xenobiotics and natural metabolite substrates--in many cases over 100-fold higher. This raises the possibility that prostaglandins are key endogenous substrates and/or that they act on the transporter in a manner different from other ...
OCTN is a small subfamily of membrane transport proteins that belongs to the larger SLC22 family. Tw...
Prostaglandins (PGs) are involved in several major signaling path-ways. Their effects are terminated...
Playing as key elements in absorption, distribution, metabolism and excretion (ADME) processes of nu...
Organic cation transporter 1 (OCT1) plays a critical role in the hepatocellular uptake of structural...
For the elimination of environmental toxins and metabolic waste products, the body is equipped with ...
Polyspecific organic cation and anion transporters of the SLC22 protein family are critically involv...
Statistical analysis was performed on physicochemical descriptors of ∼250 drugs known to interact wi...
For the elimination of environmental toxins and metabolic waste products, the body is equipped with ...
The SLC22 family of OATs, OCTs, and OCTNs is emerging as a central hub of endogenous physiology. Des...
The organic cation transporter 1 (OCT1, SLC22A1) transports a large number of structurally diverse e...
Members of the Solute Carrier (SLC) 22 family of transporters have been studied extensively due to t...
Polyspecific organic cation transporters (OCTs) of the SLC22 family mediate downhill transport of or...
The organic anion transporting polypeptide 2B1 (OATP2B1) was one of the first cloned members of the ...
Solute carrier transporters, previously thought to perform roles in the transport of ions and variou...
Prostaglandin E(2) (PGE(2)) triggers a vast array of biological signals and physiological events. Th...
OCTN is a small subfamily of membrane transport proteins that belongs to the larger SLC22 family. Tw...
Prostaglandins (PGs) are involved in several major signaling path-ways. Their effects are terminated...
Playing as key elements in absorption, distribution, metabolism and excretion (ADME) processes of nu...
Organic cation transporter 1 (OCT1) plays a critical role in the hepatocellular uptake of structural...
For the elimination of environmental toxins and metabolic waste products, the body is equipped with ...
Polyspecific organic cation and anion transporters of the SLC22 protein family are critically involv...
Statistical analysis was performed on physicochemical descriptors of ∼250 drugs known to interact wi...
For the elimination of environmental toxins and metabolic waste products, the body is equipped with ...
The SLC22 family of OATs, OCTs, and OCTNs is emerging as a central hub of endogenous physiology. Des...
The organic cation transporter 1 (OCT1, SLC22A1) transports a large number of structurally diverse e...
Members of the Solute Carrier (SLC) 22 family of transporters have been studied extensively due to t...
Polyspecific organic cation transporters (OCTs) of the SLC22 family mediate downhill transport of or...
The organic anion transporting polypeptide 2B1 (OATP2B1) was one of the first cloned members of the ...
Solute carrier transporters, previously thought to perform roles in the transport of ions and variou...
Prostaglandin E(2) (PGE(2)) triggers a vast array of biological signals and physiological events. Th...
OCTN is a small subfamily of membrane transport proteins that belongs to the larger SLC22 family. Tw...
Prostaglandins (PGs) are involved in several major signaling path-ways. Their effects are terminated...
Playing as key elements in absorption, distribution, metabolism and excretion (ADME) processes of nu...