Tubulin inhibitors are effective anticancer agents, however, there are many limitations to the use of available tubulin inhibitors in the clinic, such as multidrug resistance, severe side-effects, and generally poor bioavailability. Thus, there is a constant need to search for novel tubulin inhibitors that can overcome these limitations. Natural product and privileged structures targeting tubulin have promoted the discovery and optimization of tubulin inhibitors. This review will focus on novel tubulin inhibitors derived from natural products and privileged structures targeting the colchicine binding site on tubulin
Tubulin is the primary target of an ever growing number of natural, semisynthetic and synthetic prod...
We report the design, synthesis, and biological evaluation of heterocyclic-fused pyrimidines as tubu...
Microtubules, formed by α- and β-tubulin heterodimer, are considered as a major target to prevent th...
Tubulin inhibitors are effective anticancer agents, however, there are many limitations to the use o...
The vital roles of microtubule in mitosis and cell division make it an attractive target for antitum...
The vital roles of microtubule in mitosis and cell division make it an attractive target for antitum...
Modulating the structure and function of tubulin and microtubules is an important route to anticance...
Modulating the structure and function of tubulin and microtubules is an important route to anticance...
Microtubules are tubulin polymer structures, which are indispensable for cell growth and division. I...
Microtubules are tubulin polymer structures, which are indispensable for cell growth and division. I...
We previously reported a potent tubulin inhibitor CH-2-77. In this study, we optimized the structure...
We previously reported a potent tubulin inhibitor CH-2-77. In this study, we optimized the structure...
Retrospective validation studies carried out on three benchmark databases containing a small fractio...
Specific modifications of colchicine followed by synthesis of its analogues have been tested in vitr...
Background/Aims: Many tubulin inhibitors are in clinical use as anti-cancer drugs. In our previous s...
Tubulin is the primary target of an ever growing number of natural, semisynthetic and synthetic prod...
We report the design, synthesis, and biological evaluation of heterocyclic-fused pyrimidines as tubu...
Microtubules, formed by α- and β-tubulin heterodimer, are considered as a major target to prevent th...
Tubulin inhibitors are effective anticancer agents, however, there are many limitations to the use o...
The vital roles of microtubule in mitosis and cell division make it an attractive target for antitum...
The vital roles of microtubule in mitosis and cell division make it an attractive target for antitum...
Modulating the structure and function of tubulin and microtubules is an important route to anticance...
Modulating the structure and function of tubulin and microtubules is an important route to anticance...
Microtubules are tubulin polymer structures, which are indispensable for cell growth and division. I...
Microtubules are tubulin polymer structures, which are indispensable for cell growth and division. I...
We previously reported a potent tubulin inhibitor CH-2-77. In this study, we optimized the structure...
We previously reported a potent tubulin inhibitor CH-2-77. In this study, we optimized the structure...
Retrospective validation studies carried out on three benchmark databases containing a small fractio...
Specific modifications of colchicine followed by synthesis of its analogues have been tested in vitr...
Background/Aims: Many tubulin inhibitors are in clinical use as anti-cancer drugs. In our previous s...
Tubulin is the primary target of an ever growing number of natural, semisynthetic and synthetic prod...
We report the design, synthesis, and biological evaluation of heterocyclic-fused pyrimidines as tubu...
Microtubules, formed by α- and β-tubulin heterodimer, are considered as a major target to prevent th...