Ubiquitin-conjugating enzyme UBE2C is highly expressed in breast microcalcification lesions.
- Chen-Pin Chou
- Nan-Chieh Huang
- Shu-Jhen Jhuang
- Huay-Ben Pan
- Nan-Jing Peng
- Jiin-Tsuey Cheng
- Chian-Feng Chen
- Jih-Jung Chen
- Tsung-Hsien Chang
DOIAbstract
Ubiquitin-conjugating enzyme 2C (UBE2C) contributes to ubiquitin-mediated proteasome degradation of cell cycle progression in breast cancer. Microcalcification (MC) is the most common mammographic feature of early breast cancer. In this study, we evaluated whether UBE2C could be a tumor marker of early breast cancer with MC found on screening mammography. UBE2C protein and mRNA expression were measured in breast core biopsy pairs of MC and adjacent non-MC breast tissue from each subject. Immunohistochemistry revealed UBE2C positivity in 69.4% of MC samples and 77.6% negativity in non-MC samples (p<0.0001). On RT-qPCR, 56.1% of malignant MC lesion samples showed high mRNA level of UBE2C and 80% of benign MC lesion samples showed a low level ...
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