IL-33 modulates both innate and adaptive immune responses at tissue sites including lung and may play critical roles in inflammatory lung disease. Although IL-33 expression can be altered upon NF-Kappa B activation, here we examine regulation by Oncostatin M, a gp130 cytokine family member, in mouse lung tissue. Responses were assessed in BALB/c mouse lung at day 7 of transient overexpression using endotracheally administered adenovirus encoding OSM (AdOSM) or empty vector (AdDel70). Whole lung extracts showed induction of IL-33 mRNA (>20-fold) and protein (10-fold increase in immunoblots) by AdOSM relative to AdDel70. Immunohistochemistry for IL-33 indicated a marked induction of nuclear staining in alveolar epithelial cells in vivo. Oncos...
The mechanism by which cigarette smoke (CS) causes chronic obstructive pulmonary disease (COPD) is p...
International audienceIL-33, a novel IL-1 family member, is crucially expressed and involved in pulm...
IL-33 is a nuclear cytokine from the IL-1 family constitutively expressed in epithelial barrier tiss...
The accumulation of extracellular matrix in lung diseases involves numerous factors, including cytok...
International audienceInterleukin (IL)-33 is crucially involved in liver pathology and drives hepato...
International audienceThe initiation and regulation of pulmonary fibrosis are not well understood. I...
BackgroundThe initiation and regulation of pulmonary fibrosis are not well understood. IL-33, an imp...
IL-33 plays an important role in inflammatory diseases including hypersensitive diseases like asthma...
(A) The amounts of IL-33 in naïve mouse whole lung homogenates were measured using ELISA at differen...
IL-33 is a tissue-derived cytokine that is abundantly expressed in the human lung, where it is invol...
International audienceIdiopathic pulmonary fibrosis is a progressive, devastating, and yet untreatab...
Cystic fibrosis is characterized by dehydration of the airway surface liquid layer with persistent m...
Alternatively activated macrophages (AAM) play a crucial role in type 2 immunity. Mice deficient in ...
BackgroundThe IL-1 family cytokine IL-33 is involved in the induction of airway inflammation in alle...
IL-33 is a well-studied cytokine that resides normally within nuclei but can be released by cell dam...
The mechanism by which cigarette smoke (CS) causes chronic obstructive pulmonary disease (COPD) is p...
International audienceIL-33, a novel IL-1 family member, is crucially expressed and involved in pulm...
IL-33 is a nuclear cytokine from the IL-1 family constitutively expressed in epithelial barrier tiss...
The accumulation of extracellular matrix in lung diseases involves numerous factors, including cytok...
International audienceInterleukin (IL)-33 is crucially involved in liver pathology and drives hepato...
International audienceThe initiation and regulation of pulmonary fibrosis are not well understood. I...
BackgroundThe initiation and regulation of pulmonary fibrosis are not well understood. IL-33, an imp...
IL-33 plays an important role in inflammatory diseases including hypersensitive diseases like asthma...
(A) The amounts of IL-33 in naïve mouse whole lung homogenates were measured using ELISA at differen...
IL-33 is a tissue-derived cytokine that is abundantly expressed in the human lung, where it is invol...
International audienceIdiopathic pulmonary fibrosis is a progressive, devastating, and yet untreatab...
Cystic fibrosis is characterized by dehydration of the airway surface liquid layer with persistent m...
Alternatively activated macrophages (AAM) play a crucial role in type 2 immunity. Mice deficient in ...
BackgroundThe IL-1 family cytokine IL-33 is involved in the induction of airway inflammation in alle...
IL-33 is a well-studied cytokine that resides normally within nuclei but can be released by cell dam...
The mechanism by which cigarette smoke (CS) causes chronic obstructive pulmonary disease (COPD) is p...
International audienceIL-33, a novel IL-1 family member, is crucially expressed and involved in pulm...
IL-33 is a nuclear cytokine from the IL-1 family constitutively expressed in epithelial barrier tiss...