Objective. Toll-like receptor 4 (TLR4) plays a central role in innate immunity. Activation of innate immune response and subsequent chronic low-grade inflammation are thought to be involved in the pathogenesis of diabetic nephropathy. In this study, we aimed to investigate whether TLR4 variants are associated with diabetic nephropathy in the Chinese population. Methods. Seven tagging single nucleotide polymorphisms (SNPs) of TLR4 based on HapMap Chinese data were genotyped in 1,455 Chinese type 2 diabetic patients. Of these patients, 622 were diagnosed with diabetic nephropathy and 833 were patients with diabetes for over 5 years but without diabetic nephropathy. Results. None of the SNPs and haplotypes showed significant association to dia...
Toll-like receptors (TLRs) are a class of receptors of the innate immune system which detect pathoge...
permits unrestricted use, distribution, and reproduction in any medium, provided the original work i...
Toll like receptor (TLR) 4 has been reported to promote inflammation in diabetic nephropathy. Howeve...
which permits unrestricted use, distribution, and reproduction in any medium, provided the original ...
Objective: Several factors either predisposing or protecting from the onset of diabetes mellitus typ...
Diabetic nephropathy (DN) is a microvascular complication that affects up to 40% of diabetic patient...
Background/aim: Toll-like receptor 4 (TLR4) is one of the regulators of the innate immune response. ...
Toll-like receptors (TLRs) are pivotal components of the innate immune response. Activation of the i...
Inflammation contributes to the tubulointerstitial lesions of diabetic nephropathy. Toll-like recept...
Toll-like receptor 4 (TLR4), the signaling receptor for lipopolysaccharides, is an important member ...
BACKGROUND: Inflammatory cytokine genes have been proposed as good candidate genes for conferring su...
Toll-like receptor 4 (TLR4), a component of the innate immune system, is recognized to promote tubul...
Background: Inflammatory cytokine genes have been proposed as good candidate genes for conferring su...
Inflammatory cytokine genes have been proposed as good candidate genes for conferring susceptibility...
Objective. The interaction between advanced glycation end products and their cellular receptor (RAGE...
Toll-like receptors (TLRs) are a class of receptors of the innate immune system which detect pathoge...
permits unrestricted use, distribution, and reproduction in any medium, provided the original work i...
Toll like receptor (TLR) 4 has been reported to promote inflammation in diabetic nephropathy. Howeve...
which permits unrestricted use, distribution, and reproduction in any medium, provided the original ...
Objective: Several factors either predisposing or protecting from the onset of diabetes mellitus typ...
Diabetic nephropathy (DN) is a microvascular complication that affects up to 40% of diabetic patient...
Background/aim: Toll-like receptor 4 (TLR4) is one of the regulators of the innate immune response. ...
Toll-like receptors (TLRs) are pivotal components of the innate immune response. Activation of the i...
Inflammation contributes to the tubulointerstitial lesions of diabetic nephropathy. Toll-like recept...
Toll-like receptor 4 (TLR4), the signaling receptor for lipopolysaccharides, is an important member ...
BACKGROUND: Inflammatory cytokine genes have been proposed as good candidate genes for conferring su...
Toll-like receptor 4 (TLR4), a component of the innate immune system, is recognized to promote tubul...
Background: Inflammatory cytokine genes have been proposed as good candidate genes for conferring su...
Inflammatory cytokine genes have been proposed as good candidate genes for conferring susceptibility...
Objective. The interaction between advanced glycation end products and their cellular receptor (RAGE...
Toll-like receptors (TLRs) are a class of receptors of the innate immune system which detect pathoge...
permits unrestricted use, distribution, and reproduction in any medium, provided the original work i...
Toll like receptor (TLR) 4 has been reported to promote inflammation in diabetic nephropathy. Howeve...