Sphingosine-1-phosphate (S1P) regulates a broad spectrum of fundamental cellular processes like proliferation, death, migration and cytokine production. Therefore, elevated levels of S1P may be causal to various pathologic conditions including cancer, fibrosis, inflammation, autoimmune diseases and aberrant angiogenesis. Here we report that S1P lyase from the prokaryote Symbiobacterium thermophilum (StSPL) degrades extracellular S1P in vitro and in blood. Moreover, we investigated its effect on cellular responses typical of fibrosis, cancer and aberrant angiogenesis using renal mesangial cells, endothelial cells, breast (MCF-7) and colon (HCT 116) carcinoma cells as disease models. In all cell types, wild-type StSPL, but not an inactive mut...
Sphingosine 1-phosphate (S1P), a lysophospholipid mediator, regulates diverse functions of many type...
Inflammation is involved in the pathogenesis of many different disorders, including glomerulonephr...
The lysophospholipid sphingosine 1-phosphate (S1P) has important roles in regulating vascular physio...
Sphingosine-1-phosphate (S1P) regulates a broad spectrum of fundamental cellular processes like prol...
The bioactive lipid sphingosine-1-phosphate (S1P) is a main regulator of cell survival, proliferatio...
<div><p>The bioactive lipid sphingosine-1-phosphate (S1P) is a main regulator of cell survival, prol...
BACKGROUND: S1PL is an aldehyde-lyase that irreversibly cleaves sphingosine 1-phosphate (S1P) in the...
Sphingosine 1-phosphate (S1P), a lysophospholipid mediator, regulates diverse functions of many type...
There is substantial evidence that sphingosine 1-phosphate (S1P) is involved in cancer. S1P regulate...
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that activates a family of G protein coupl...
The enzymes that catalyze formation of the bioactive sphingolipid, sphingosine 1-phosphate, sphingos...
[[abstract]]Sphingosine 1-phosphate (S1P), a lysophospholipid mediator, regulates diverse functions ...
This is the first report of sphingosine 1-phosphate lyase (SPL) protein expression and enzymatic act...
The lymphatic system plays pivotal roles in mediating tissue fluid homeostasis and immunity, and exc...
BACKGROUND: Earlier we have shown that extracellular sphingosine-1-phosphate (S1P) induces migration...
Sphingosine 1-phosphate (S1P), a lysophospholipid mediator, regulates diverse functions of many type...
Inflammation is involved in the pathogenesis of many different disorders, including glomerulonephr...
The lysophospholipid sphingosine 1-phosphate (S1P) has important roles in regulating vascular physio...
Sphingosine-1-phosphate (S1P) regulates a broad spectrum of fundamental cellular processes like prol...
The bioactive lipid sphingosine-1-phosphate (S1P) is a main regulator of cell survival, proliferatio...
<div><p>The bioactive lipid sphingosine-1-phosphate (S1P) is a main regulator of cell survival, prol...
BACKGROUND: S1PL is an aldehyde-lyase that irreversibly cleaves sphingosine 1-phosphate (S1P) in the...
Sphingosine 1-phosphate (S1P), a lysophospholipid mediator, regulates diverse functions of many type...
There is substantial evidence that sphingosine 1-phosphate (S1P) is involved in cancer. S1P regulate...
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that activates a family of G protein coupl...
The enzymes that catalyze formation of the bioactive sphingolipid, sphingosine 1-phosphate, sphingos...
[[abstract]]Sphingosine 1-phosphate (S1P), a lysophospholipid mediator, regulates diverse functions ...
This is the first report of sphingosine 1-phosphate lyase (SPL) protein expression and enzymatic act...
The lymphatic system plays pivotal roles in mediating tissue fluid homeostasis and immunity, and exc...
BACKGROUND: Earlier we have shown that extracellular sphingosine-1-phosphate (S1P) induces migration...
Sphingosine 1-phosphate (S1P), a lysophospholipid mediator, regulates diverse functions of many type...
Inflammation is involved in the pathogenesis of many different disorders, including glomerulonephr...
The lysophospholipid sphingosine 1-phosphate (S1P) has important roles in regulating vascular physio...