Mesenchymal stem cells (MSCs) can be successfully induced to differentiate into insulin-producing cells (IPCs) by a variety of small molecules and cytokines in vitro. However, problems remain, such as low transdifferentiation efficiency and poor maturity of trans-differentiated cells. The damaged pancreatic cells secreted a large amount of soluble proteins, which were able to promote pancreative islet regeneration and MSCs differentiation. In this study, we utilized the rat injured pancreatic tissue extract to modulate rat bone marrow-derived MSCs differentiation into IPCs by the traditional two-step induction. Our results showed that injured pancreatic tissue extract could effectively promote the trans-differentiation efficiency and maturi...
Type 1 diabetes mellitus is a result of autoimmune destruction of pancreatic insulin producing -cell...
Background: Adipose tissue-derived mesenchymal stem cells (AD-MSCs) were proved to differentiate int...
Type 1 diabetes mellitus is a result of autoimmune destruction of pancreatic insulin producing β-cel...
Mesenchymal stem cells (MSCs) can be successfully induced to differentiate into insulin-producing ce...
The direct co-culturing effect of rat bone-marrow-derived mesenchymal stem cells (rBM-MSCs) on the p...
Background: Cell-therapy provides a promising alternative for the treatment of type 1 diabetes. Mono...
The clinical usability of pancreatic islet transplantation for the treatment of type I diabetes, des...
Objective: Pancreatic stroma plays an important role in the induction of pancreatic cells by the us...
Due to their ability in self-renewing and differentiation into a wide variety of tissues, mesenchyma...
The clinical usability of pancreatic islet transplantation for the treatment of type I diabetes, des...
Aim: Various studies have shown that secreted factors alone in culture medium without stem cell are ...
Transdifferentiation potential of mesenchymal stem cells (MSCs) into insulin-producing cells (IPCs) ...
Adipose or fatty tissue is similar to bone marrow ontogenetically. Mesenchymal stem cells can be iso...
Diabetes mellitus (D.M) is a disease with a high and increasing prevalence. Insulin-producing cells ...
The clinical usability of pancreatic islet transplantation for the treatment of type I diabetes, des...
Type 1 diabetes mellitus is a result of autoimmune destruction of pancreatic insulin producing -cell...
Background: Adipose tissue-derived mesenchymal stem cells (AD-MSCs) were proved to differentiate int...
Type 1 diabetes mellitus is a result of autoimmune destruction of pancreatic insulin producing β-cel...
Mesenchymal stem cells (MSCs) can be successfully induced to differentiate into insulin-producing ce...
The direct co-culturing effect of rat bone-marrow-derived mesenchymal stem cells (rBM-MSCs) on the p...
Background: Cell-therapy provides a promising alternative for the treatment of type 1 diabetes. Mono...
The clinical usability of pancreatic islet transplantation for the treatment of type I diabetes, des...
Objective: Pancreatic stroma plays an important role in the induction of pancreatic cells by the us...
Due to their ability in self-renewing and differentiation into a wide variety of tissues, mesenchyma...
The clinical usability of pancreatic islet transplantation for the treatment of type I diabetes, des...
Aim: Various studies have shown that secreted factors alone in culture medium without stem cell are ...
Transdifferentiation potential of mesenchymal stem cells (MSCs) into insulin-producing cells (IPCs) ...
Adipose or fatty tissue is similar to bone marrow ontogenetically. Mesenchymal stem cells can be iso...
Diabetes mellitus (D.M) is a disease with a high and increasing prevalence. Insulin-producing cells ...
The clinical usability of pancreatic islet transplantation for the treatment of type I diabetes, des...
Type 1 diabetes mellitus is a result of autoimmune destruction of pancreatic insulin producing -cell...
Background: Adipose tissue-derived mesenchymal stem cells (AD-MSCs) were proved to differentiate int...
Type 1 diabetes mellitus is a result of autoimmune destruction of pancreatic insulin producing β-cel...