Lipoprotein lipase (Lpl) acts on triglyceride-rich lipoproteins in the peripheral circulation, liberating free fatty acids for energy metabolism or storage. This essential enzyme is synthesized in parenchymal cells of adipose tissue, heart, and skeletal muscle and migrates to the luminal side of the vascular endothelium where it acts upon circulating lipoproteins. Prior studies suggested that Lpl is immobilized by way of heparan sulfate proteoglycans on the endothelium, but genetically altering endothelial cell heparan sulfate had no effect on Lpl localization or lipolysis. The objective of this study was to determine if extracellular matrix proteoglycans affect Lpl distribution and triglyceride metabolism.We examined mutant mice defective ...
Altered metabolism with excess provision of lipid sub-strates may be a major pathogenetic factor lin...
Lipoprotein lipase (LPL) plays a central role in triglyceride metabolism, regulating the catabolism ...
Lipoprotein lipase (LPL) hydrolyses blood lipids at the vascular endothelium. This action makes fatt...
Lipoprotein lipase (Lpl) acts on triglyceride-rich lipoproteins in the peripheral circulation, liber...
BackgroundLipoprotein lipase (Lpl) acts on triglyceride-rich lipoproteins in the peripheral circulat...
Peripheral lipoprotein lipase (LPL)-mediated lipolysis of triglycerides is the first step in chylomi...
GPIHBP1, an endothelial cell (EC) protein, captures lipoprotein lipase (LPL) within the interstitial...
Triglyceride-rich lipoproteins (TRLs) undergo lipolysis by lipoprotein lipase (LPL), an enzyme that ...
Triglyceride-rich lipoproteins (TRLs) undergo lipolysis by lipoprotein lipase (LPL), an enzyme that ...
Objective—Low density lipoprotein (LDL) receptor–related protein (LRP) binds and internalizes aggreg...
The role of the enzyme lipoprotein lipase (LPL) in atherosclerosis is uncertain. To generate an anim...
AbstractLipoprotein lipase (LPL) plays a central role in triglyceride metabolism, regulating the cat...
Heparan sulfate proteoglycans mediate multiple aspects of triglyceride-rich lipoprotein metabolism t...
Adipose fat storage is thought to require uptake of circulating triglyceride (TG)-derived fatty acid...
Triglyceride-rich lipoproteins (TRLs) undergo lipolysis by lipoprotein lipase (LPL), an enzyme that ...
Altered metabolism with excess provision of lipid sub-strates may be a major pathogenetic factor lin...
Lipoprotein lipase (LPL) plays a central role in triglyceride metabolism, regulating the catabolism ...
Lipoprotein lipase (LPL) hydrolyses blood lipids at the vascular endothelium. This action makes fatt...
Lipoprotein lipase (Lpl) acts on triglyceride-rich lipoproteins in the peripheral circulation, liber...
BackgroundLipoprotein lipase (Lpl) acts on triglyceride-rich lipoproteins in the peripheral circulat...
Peripheral lipoprotein lipase (LPL)-mediated lipolysis of triglycerides is the first step in chylomi...
GPIHBP1, an endothelial cell (EC) protein, captures lipoprotein lipase (LPL) within the interstitial...
Triglyceride-rich lipoproteins (TRLs) undergo lipolysis by lipoprotein lipase (LPL), an enzyme that ...
Triglyceride-rich lipoproteins (TRLs) undergo lipolysis by lipoprotein lipase (LPL), an enzyme that ...
Objective—Low density lipoprotein (LDL) receptor–related protein (LRP) binds and internalizes aggreg...
The role of the enzyme lipoprotein lipase (LPL) in atherosclerosis is uncertain. To generate an anim...
AbstractLipoprotein lipase (LPL) plays a central role in triglyceride metabolism, regulating the cat...
Heparan sulfate proteoglycans mediate multiple aspects of triglyceride-rich lipoprotein metabolism t...
Adipose fat storage is thought to require uptake of circulating triglyceride (TG)-derived fatty acid...
Triglyceride-rich lipoproteins (TRLs) undergo lipolysis by lipoprotein lipase (LPL), an enzyme that ...
Altered metabolism with excess provision of lipid sub-strates may be a major pathogenetic factor lin...
Lipoprotein lipase (LPL) plays a central role in triglyceride metabolism, regulating the catabolism ...
Lipoprotein lipase (LPL) hydrolyses blood lipids at the vascular endothelium. This action makes fatt...