Mean platelet volume (MPV) analysis in patients with coronary artery disease

ABSTRACT Platelets have a predominant role in the pathogenesis of Acute Coronary Syndromes (ACS). It is believed that the mean platelet size, evaluated by the mean platelet volume (MPV), is a sensitive indicator of platelet reactivity and trombogenicity potential. Several studies have found associations between the MPV and the ACS or the occurrence of Acute Myocardial Infarction (AMI). The reasons for this are not very well known, but may be due to platelet aggregation or consumption. The aim of this study was to identify a relation between the MPV value and the presence of coronary artery disease, and between alterations in this value and risk factors for coronary artery disease, such as age, sex, hypertension, diabetes, smoking, dislipidemia, obesity and family history. All patients (N = 72) had an elevated MPV, mean of 11.57 fL. No statistically significance was found in the groups with different risk