The gene of Cytotoxic T Lymphocyte-associated Antigen 4 (CTLA4), a negative regulator of T lymphocytes, contains a single-nucleotide polymorphism (SNP) at position +6230A->G (ct60A->G), which has been found associated with several autoimmune diseases and appears to reduce T-cell inhibitory activity. In Ghana, West Africa, we compared the frequencies of CTLA4 +6230 A/G and 6 haplotype-tagging SNPs in 2010 smear-positive, HIV-negative patients with pulmonary tuberculosis (TB) and 2346 controls matched for age, gender and ethnicity. We found no difference in allele frequencies between cases and controls. However, +6230A and a distinct CTLA4 haplotype and a diplotype comprising the +6230A allele were significantly less frequent among cases with...
ABSTRACT Tuberculosis (TB) remains a major cause of morbidity and mortality worldwide. Mycobacterium...
Twenty-seven polymorphisms from 12 genes have been investigated for association with tuberculosis (T...
The PTPN22 gene codes for an intracellular lymphoid-specific phosphatase (Lyp) that has a negative r...
SETTING: Host genetic risk factors influence susceptibility to tuberculosis (TB). There is ample evi...
Tuberculosis (TB) is a major health problem which causes many deaths every year in the world. Accord...
Several host and environmental factors contribute to tuberculosis outcome, interestingly single nucl...
BACKGROUND: Tuberculosis causes significant morbidity and mortality worldwide, especially in sub-Sah...
1<p>Seven tagging SNPs reported to appropriately indicate <i>CTLA4</i> haplotypes in sub-Saharan Afr...
Background: Tuberculosis causes significant morbidity and mortality worldwide, especially in su...
There is now considerable evidence that host genetic factors are important in determining the outcom...
Pulmonary tuberculosis (TB), caused by Mycobacterium tuberculosis, is a complex disease. The risk of...
There is now considerable evidence that host genetic factors are important in determining the outcom...
SETTING: Tuberculosis (TB) remains a major cause of morbidity and mortality worldwide. Studies in a ...
Twenty-seven polymorphisms from 12 genes have been investigated for association with tuberculosis (T...
The C-C motif chemokine ligand-2 (CCL2) was evidenced to be associated with tuberculosis susceptibil...
ABSTRACT Tuberculosis (TB) remains a major cause of morbidity and mortality worldwide. Mycobacterium...
Twenty-seven polymorphisms from 12 genes have been investigated for association with tuberculosis (T...
The PTPN22 gene codes for an intracellular lymphoid-specific phosphatase (Lyp) that has a negative r...
SETTING: Host genetic risk factors influence susceptibility to tuberculosis (TB). There is ample evi...
Tuberculosis (TB) is a major health problem which causes many deaths every year in the world. Accord...
Several host and environmental factors contribute to tuberculosis outcome, interestingly single nucl...
BACKGROUND: Tuberculosis causes significant morbidity and mortality worldwide, especially in sub-Sah...
1<p>Seven tagging SNPs reported to appropriately indicate <i>CTLA4</i> haplotypes in sub-Saharan Afr...
Background: Tuberculosis causes significant morbidity and mortality worldwide, especially in su...
There is now considerable evidence that host genetic factors are important in determining the outcom...
Pulmonary tuberculosis (TB), caused by Mycobacterium tuberculosis, is a complex disease. The risk of...
There is now considerable evidence that host genetic factors are important in determining the outcom...
SETTING: Tuberculosis (TB) remains a major cause of morbidity and mortality worldwide. Studies in a ...
Twenty-seven polymorphisms from 12 genes have been investigated for association with tuberculosis (T...
The C-C motif chemokine ligand-2 (CCL2) was evidenced to be associated with tuberculosis susceptibil...
ABSTRACT Tuberculosis (TB) remains a major cause of morbidity and mortality worldwide. Mycobacterium...
Twenty-seven polymorphisms from 12 genes have been investigated for association with tuberculosis (T...
The PTPN22 gene codes for an intracellular lymphoid-specific phosphatase (Lyp) that has a negative r...