Several reports have demonstrated a role for aberrant NOTCH signaling in melanoma genesis and progression, prompting us to explore if targeting this pathway is a valid therapeutic approach against melanoma. We targeted NOTCH signaling using RO4929097, a novel inhibitor of gamma secretase, which is a key component of the enzymatic complex that cleaves and activates NOTCH. The effects of RO4929097 on the oncogenic and stem cell properties of a panel of melanoma cell lines were tested both in vitro and in vivo, using xenograft models. In human primary melanoma cell lines, RO4929097 decreased the levels of NOTCH transcriptional target HES1. This was accompanied by reduced proliferation and impaired ability to form colonies in soft agar and to o...
Glioblastoma (GBM) is the most common primary adult brain tumor. The Notch pathway has been identifi...
Despite modern achievements in therapy of malignant melanomas new treatment strategies are welcomed ...
The crosstalk between Notch and MAPK pathway plays a role in MEK inhibitor resistance in BRAFV600E m...
Several reports have demonstrated a role for aberrant NOTCH signaling in melanoma genesis and progre...
Notch receptor-mediated intracellular events represent an ancient cell signaling system, and alterat...
BackgroundAberrant Notch activation confers a proliferative advantage to many human tumors, includin...
Deregulation of NOTCH2 signaling is implicated in a wide variety of human neoplasias. The current co...
RO4929097 is a potent and selective inhibitor of gamma-secretase and as a result is able to inhibit ...
Pancreatic cancer stem cells (CSCs) represent a small subpopulation of pancreatic cancer cells that ...
Accumulating preclinical and clinical evidence supports a pro-oncogenic function for Notch signaling...
BACKGROUND: Notch signalling is essential for the development and maintenance of the colonic epithel...
Jianxun Han,1 Qiang Shen21Department of Chemical Engineering and Applied Chemistry, University of To...
Pancreatic cancer stem cells (CSCs) represent a small subpopulation of pancreatic cancer cells that ...
Abstract Background Notch signalling is essential for the development and maintenance of the colonic...
Pancreatic ductal adenocarcinoma (PDA) is a highly lethal disease that is refractory to medical inte...
Glioblastoma (GBM) is the most common primary adult brain tumor. The Notch pathway has been identifi...
Despite modern achievements in therapy of malignant melanomas new treatment strategies are welcomed ...
The crosstalk between Notch and MAPK pathway plays a role in MEK inhibitor resistance in BRAFV600E m...
Several reports have demonstrated a role for aberrant NOTCH signaling in melanoma genesis and progre...
Notch receptor-mediated intracellular events represent an ancient cell signaling system, and alterat...
BackgroundAberrant Notch activation confers a proliferative advantage to many human tumors, includin...
Deregulation of NOTCH2 signaling is implicated in a wide variety of human neoplasias. The current co...
RO4929097 is a potent and selective inhibitor of gamma-secretase and as a result is able to inhibit ...
Pancreatic cancer stem cells (CSCs) represent a small subpopulation of pancreatic cancer cells that ...
Accumulating preclinical and clinical evidence supports a pro-oncogenic function for Notch signaling...
BACKGROUND: Notch signalling is essential for the development and maintenance of the colonic epithel...
Jianxun Han,1 Qiang Shen21Department of Chemical Engineering and Applied Chemistry, University of To...
Pancreatic cancer stem cells (CSCs) represent a small subpopulation of pancreatic cancer cells that ...
Abstract Background Notch signalling is essential for the development and maintenance of the colonic...
Pancreatic ductal adenocarcinoma (PDA) is a highly lethal disease that is refractory to medical inte...
Glioblastoma (GBM) is the most common primary adult brain tumor. The Notch pathway has been identifi...
Despite modern achievements in therapy of malignant melanomas new treatment strategies are welcomed ...
The crosstalk between Notch and MAPK pathway plays a role in MEK inhibitor resistance in BRAFV600E m...