Nitric oxide (NO) has been shown to improve wound healing, but the mechanism underlying this function is not well defined. Here, we explored the effect of NO on the migration of a human keratinocyte cell line (HaCaT) and its possible mechanism.The effects of NO on HaCaT cells in the presence of different concentrations of the NO donor sodium nitroprusside (SNP) were evaluated in a cell migration assay. Subsequently, the cytoskeleton reorganization of cultured HaCaT cells stained with rhodamine-phalloidin was observed with a confocal laser scanning microscope. The mRNA expression and active proteins of CDC42, Rac1 and RhoA in the cultured cells were determined via RT-PCR and pull-down assays, respectively. Furthermore, the roles of various i...
Activation of the aryl hydrocarbon receptor (AHR) in normal human epidermal keratinocytes (NHEKs) ac...
Expression of nNOS mRNA was found in normal human and mouse skin tissue. Upon wounding, we observed ...
Activation of the aryl hydrocarbon receptor (AHR) in normal human epidermal keratinocytes (NHEKs) ac...
Nitric oxide (NO) has been shown to improve wound healing, but the mechanism underlying this functio...
Objective Nitric oxide (NO) has been shown to improve wound healing, but the mechanism underlying th...
During tissue injury and wound healing process, there are dynamic reciprocal interactions among cell...
During tissue injury and wound healing process, there are dynamic reciprocal interactions among cell...
During tissue injury and wound healing process, there are dynamic reciprocal interactions among cell...
Smooth muscle cell (SMC) migration contributes to vascular remodeling. Nitric oxide (NO) produced vi...
Nitric oxide (NO) donors have been shown to improve wound healing, but the mechanism is not well def...
Nitric oxide (NO) donors have been shown to improve wound healing, but the mechanism is not well def...
Nitric oxide (NO) is known to exert cytotoxic and cytostatic effects in various cells and tissues. A...
Recently, we demonstrated a large induction of inducible nitric oxide synthase (iNOS) during cutaneo...
Smooth muscle cell (SMC) migration contributes to vascular remodeling. Nitric oxide (NO) produced vi...
<p>(a) Treatment with a cGMP agonist (8-Br-cGMP, 1 μM) or PKG agonist (8-pCPT-cGMP, 1 μM) alone. The...
Activation of the aryl hydrocarbon receptor (AHR) in normal human epidermal keratinocytes (NHEKs) ac...
Expression of nNOS mRNA was found in normal human and mouse skin tissue. Upon wounding, we observed ...
Activation of the aryl hydrocarbon receptor (AHR) in normal human epidermal keratinocytes (NHEKs) ac...
Nitric oxide (NO) has been shown to improve wound healing, but the mechanism underlying this functio...
Objective Nitric oxide (NO) has been shown to improve wound healing, but the mechanism underlying th...
During tissue injury and wound healing process, there are dynamic reciprocal interactions among cell...
During tissue injury and wound healing process, there are dynamic reciprocal interactions among cell...
During tissue injury and wound healing process, there are dynamic reciprocal interactions among cell...
Smooth muscle cell (SMC) migration contributes to vascular remodeling. Nitric oxide (NO) produced vi...
Nitric oxide (NO) donors have been shown to improve wound healing, but the mechanism is not well def...
Nitric oxide (NO) donors have been shown to improve wound healing, but the mechanism is not well def...
Nitric oxide (NO) is known to exert cytotoxic and cytostatic effects in various cells and tissues. A...
Recently, we demonstrated a large induction of inducible nitric oxide synthase (iNOS) during cutaneo...
Smooth muscle cell (SMC) migration contributes to vascular remodeling. Nitric oxide (NO) produced vi...
<p>(a) Treatment with a cGMP agonist (8-Br-cGMP, 1 μM) or PKG agonist (8-pCPT-cGMP, 1 μM) alone. The...
Activation of the aryl hydrocarbon receptor (AHR) in normal human epidermal keratinocytes (NHEKs) ac...
Expression of nNOS mRNA was found in normal human and mouse skin tissue. Upon wounding, we observed ...
Activation of the aryl hydrocarbon receptor (AHR) in normal human epidermal keratinocytes (NHEKs) ac...