Cu/Zn superoxide dismutase (SOD1) knockout (KO) mice are known as an aging model in some aspects, but the damage and regeneration process of each fiber type have not been sufficiently studied. In this study, we investigated the damage and satellite cell state of the gastrocnemius muscle in SOD1 KO mice (6 months old) using immunohistochemical staining and real-time RT-PCR. The proportion of central nuclei-containing Type IIx/b fibers in the deep and superficial portions of the gastrocnemius muscle was significantly higher in SOD1 KO than control mice. The number of satellite cells per muscle fiber decreased in all muscle fiber types in the deep portion of the gastrocnemius muscle in SOD1 KO mice. In addition, the mRNA expression levels of P...
Age-related loss of muscle mass and function often referred to as sarcopenia, dramatically affects t...
<p>(A) Expression of PGC1-α, PPARα and PDK4 in gastrocnemius and tibialis anterior from SCD1 knockou...
[[abstract]]Skeletal muscle has emerged as one of the most important tissues involved in regulating ...
Elevated reactive oxygen species (ROS) production and ROS-dependent protein damage is a common obser...
Aims: Lack of Cu,Zn-superoxide dismutase (CuZnSOD) in homozygous knockout mice (Sod1−/−) leads to ac...
AbstractOur previous studies showed that adult (8 month) mice lacking CuZn-superoxide dismutase (CuZ...
The antioxidant enzyme superoxide dismutase 1 (SOD1) is a critical player of the antioxidative defen...
The antioxidant enzyme superoxide dismutase 1 (SOD1) is a critical player of the antioxidative defen...
In muscle, aging is associated with a failure of adaptive responses to contractile activity, and thi...
SummaryThe antioxidant enzyme superoxide dismutase 1 (SOD1) is a critical player of the antioxidativ...
The antioxidant enzyme superoxide dismutase 1 (SOD1) is a critical player of the antioxidative defen...
Metabolic conditions such as obesity, insulin resistance and glucose intolerance are frequently asso...
Metabolic conditions such as obesity, insulin resistance and glucose intolerance are frequently asso...
Age-related loss of muscle mass and function often referred to as sarcopenia, dramatically affects t...
Aims: Lack of Cu,Zn-superoxide dismutase (CuZnSOD) in homozygous knockout mice (Sod1−/−) leads to ac...
Age-related loss of muscle mass and function often referred to as sarcopenia, dramatically affects t...
<p>(A) Expression of PGC1-α, PPARα and PDK4 in gastrocnemius and tibialis anterior from SCD1 knockou...
[[abstract]]Skeletal muscle has emerged as one of the most important tissues involved in regulating ...
Elevated reactive oxygen species (ROS) production and ROS-dependent protein damage is a common obser...
Aims: Lack of Cu,Zn-superoxide dismutase (CuZnSOD) in homozygous knockout mice (Sod1−/−) leads to ac...
AbstractOur previous studies showed that adult (8 month) mice lacking CuZn-superoxide dismutase (CuZ...
The antioxidant enzyme superoxide dismutase 1 (SOD1) is a critical player of the antioxidative defen...
The antioxidant enzyme superoxide dismutase 1 (SOD1) is a critical player of the antioxidative defen...
In muscle, aging is associated with a failure of adaptive responses to contractile activity, and thi...
SummaryThe antioxidant enzyme superoxide dismutase 1 (SOD1) is a critical player of the antioxidativ...
The antioxidant enzyme superoxide dismutase 1 (SOD1) is a critical player of the antioxidative defen...
Metabolic conditions such as obesity, insulin resistance and glucose intolerance are frequently asso...
Metabolic conditions such as obesity, insulin resistance and glucose intolerance are frequently asso...
Age-related loss of muscle mass and function often referred to as sarcopenia, dramatically affects t...
Aims: Lack of Cu,Zn-superoxide dismutase (CuZnSOD) in homozygous knockout mice (Sod1−/−) leads to ac...
Age-related loss of muscle mass and function often referred to as sarcopenia, dramatically affects t...
<p>(A) Expression of PGC1-α, PPARα and PDK4 in gastrocnemius and tibialis anterior from SCD1 knockou...
[[abstract]]Skeletal muscle has emerged as one of the most important tissues involved in regulating ...