It has recently been determined that not only Aβ oligomers, but also other Aβ species and amyloidogenic peptides are neurotoxic in Alzheimer disease (AD) and play a pivotal role in AD pathogenesis. In the present study, we attempted to develop new DNA vaccines targeting a wide range of Aβ species. For this purpose, we first performed in vitro assays with newly developed vaccines to evaluate Aβ production and Aβ secretion abilities and then chose an IgL-Aβx4-Fc-IL-4 vaccine (designated YM3711) for further studies. YM3711 was vaccinated to mice, rabbits and monkeys to evaluate anti-Aβ species antibody-producing ability and Aβ reduction effects. It was found that YM3711 vaccination induced significantly higher levels of antibodies not only to ...
Abstract Background It is well established that vaccination of humans and transgenic animals against...
Immunization against amyloid-β (Aβ) can reduce amyloid accumulation in vivo and is considered a pote...
Immunization against amyloid-beta-peptide (Aβ) has been widely investigated as a potential immunothe...
It has recently been determined that not only Ab oligomers, but also other Ab species and amyloidoge...
The cause of Alzheimer's disease is still unknown, but the disease is distinctively characterized by...
AbstractBackgroundβ-Amyloid peptide (Aβ) oligomers are initial factors used to induce Alzheimer’s di...
Abstract Background Alzheimer’s disease (AD) is the most well-known and most common type of age-rela...
The neuropathology of Alzheimer's disease(AD) is characterized by the accumulation of amyloid peptid...
Immunization against β-amyloid (Aβ) is pursued as a possible strategy for the prevention of Alzheime...
<div><p>Recent evidence suggests Alzheimer-Disease (AD) to be driven by aggregated Aß. Capitalizing ...
The cause of Alzheimer’s disease is still unknown, but the disease is distinctively characterized by...
Active immunization with fibrillar beta-amyloid peptide (AB42) as well as passive transfer of anti-A...
The DNA vaccine, AV-1959D, targeting N-terminal epitope of Aβ peptide, has been proven immunogenic i...
BackgroundAlzheimer's disease, a common dementia of the elder, is characterized by accumulation of p...
Alzheimer’s disease results from an accumulation of aggregated amyloid beta peptide into oligomeric ...
Abstract Background It is well established that vaccination of humans and transgenic animals against...
Immunization against amyloid-β (Aβ) can reduce amyloid accumulation in vivo and is considered a pote...
Immunization against amyloid-beta-peptide (Aβ) has been widely investigated as a potential immunothe...
It has recently been determined that not only Ab oligomers, but also other Ab species and amyloidoge...
The cause of Alzheimer's disease is still unknown, but the disease is distinctively characterized by...
AbstractBackgroundβ-Amyloid peptide (Aβ) oligomers are initial factors used to induce Alzheimer’s di...
Abstract Background Alzheimer’s disease (AD) is the most well-known and most common type of age-rela...
The neuropathology of Alzheimer's disease(AD) is characterized by the accumulation of amyloid peptid...
Immunization against β-amyloid (Aβ) is pursued as a possible strategy for the prevention of Alzheime...
<div><p>Recent evidence suggests Alzheimer-Disease (AD) to be driven by aggregated Aß. Capitalizing ...
The cause of Alzheimer’s disease is still unknown, but the disease is distinctively characterized by...
Active immunization with fibrillar beta-amyloid peptide (AB42) as well as passive transfer of anti-A...
The DNA vaccine, AV-1959D, targeting N-terminal epitope of Aβ peptide, has been proven immunogenic i...
BackgroundAlzheimer's disease, a common dementia of the elder, is characterized by accumulation of p...
Alzheimer’s disease results from an accumulation of aggregated amyloid beta peptide into oligomeric ...
Abstract Background It is well established that vaccination of humans and transgenic animals against...
Immunization against amyloid-β (Aβ) can reduce amyloid accumulation in vivo and is considered a pote...
Immunization against amyloid-beta-peptide (Aβ) has been widely investigated as a potential immunothe...