The life stages of Leishmania spp. include the infectious promastigote and the replicative intracellular amastigote. Each stage is phagocytosed by macrophages during the parasite life cycle. We previously showed that caveolae, a subset of cholesterol-rich membrane lipid rafts, facilitate uptake and intracellular survival of virulent promastigotes by macrophages, at least in part, by delaying parasitophorous vacuole (PV)-lysosome fusion. We hypothesized that amastigotes and promastigotes would differ in their route of macrophage entry and mechanism of PV maturation. Indeed, transient disruption of macrophage lipid rafts decreased the entry of promastigotes, but not amastigotes, into macrophages (P<0.001). Promastigote-containing PVs were pos...
The last step of Leishmania intracellular life cycle is the egress of amastigotes from the host cell...
Survival or destruction of intramacrophage pathogen Leishmania depends in part on modulation of thei...
<div><p>An important area in the cell biology of intracellular parasitism is the customization of pa...
International audienceThe parasitophorous vacuoles (PVs) that insulate Leishmania spp. in host macro...
The parasitophorous vacuoles (PVs) that insulate Leishmania spp. in host macrophages are vacuolar co...
The initial macrophage–Leishmania donovani interaction results in the formation of membrane platform...
Leishmania have a digenetic life cycle, involving a motile, extracellular stage (promastigote) which...
Leishmania donovani-infected splenic macrophages and P388D1 (P388D1(I)) failed to activate T cells i...
Infectivity of Leishmania promastigotes has been shown to be growth cycle-dependent and restricted t...
Leishmania is a trypanosomatid protozoan that is responsible for the disease leishmaniasis. Promasti...
The small GTPase Rab5 is a key regulator of endosome/phagosome maturation and in intravesicular infe...
<div><p><i>Leishmania</i>, the causative agent of vector-borne diseases, known as leishmaniases, is ...
International audienceLeishmania, the causative agent of vector-borne diseases, known as leishmanias...
In this thesis, we investigated the interaction of the obligate intracellular parasite Leishmania (L...
Leishmania donovani is an obligate intracellular parasite that infects macrophages of the vertebrate...
The last step of Leishmania intracellular life cycle is the egress of amastigotes from the host cell...
Survival or destruction of intramacrophage pathogen Leishmania depends in part on modulation of thei...
<div><p>An important area in the cell biology of intracellular parasitism is the customization of pa...
International audienceThe parasitophorous vacuoles (PVs) that insulate Leishmania spp. in host macro...
The parasitophorous vacuoles (PVs) that insulate Leishmania spp. in host macrophages are vacuolar co...
The initial macrophage–Leishmania donovani interaction results in the formation of membrane platform...
Leishmania have a digenetic life cycle, involving a motile, extracellular stage (promastigote) which...
Leishmania donovani-infected splenic macrophages and P388D1 (P388D1(I)) failed to activate T cells i...
Infectivity of Leishmania promastigotes has been shown to be growth cycle-dependent and restricted t...
Leishmania is a trypanosomatid protozoan that is responsible for the disease leishmaniasis. Promasti...
The small GTPase Rab5 is a key regulator of endosome/phagosome maturation and in intravesicular infe...
<div><p><i>Leishmania</i>, the causative agent of vector-borne diseases, known as leishmaniases, is ...
International audienceLeishmania, the causative agent of vector-borne diseases, known as leishmanias...
In this thesis, we investigated the interaction of the obligate intracellular parasite Leishmania (L...
Leishmania donovani is an obligate intracellular parasite that infects macrophages of the vertebrate...
The last step of Leishmania intracellular life cycle is the egress of amastigotes from the host cell...
Survival or destruction of intramacrophage pathogen Leishmania depends in part on modulation of thei...
<div><p>An important area in the cell biology of intracellular parasitism is the customization of pa...