Inverse Association between Prediagnostic IgE Levels and the Risk of Brain Tumors: A Systematic Review and Meta-Analysis

Chong Ma
Lei Cao
Jianping Zhao
Xing Ming
Ming Shang
Hailiang Zong
Hai Du
Kai Li
Xiaoguang He
Hongsheng Xu

Open link

Publication date

January 2015

DOI

10.1155/2015/294213

Publisher

Hindawi Limited

ISSN

2314-6133

Journal

2314-6141

Citation count (estimate)

Abstract

An inverse association between allergic conditions and glioma risk has been suggested in many epidemiological studies. However, the evidence is inadequate to draw robust conclusions for the association between prediagnostic IgE levels and brain tumors risk. The aim of this study was to provide more precise estimates for this association by meta-analysis of all published studies. Overall, 8 individual studies with 2,461 cases and 3,934 controls were included in our study. A decreased risk of brain tumors (RR = 0.73, 95% CI 0.61–0.86, P<0.001) was observed in relation to elevated level of total IgE. The negative association was significant between elevated total IgE level and the risk of glioma (RR = 0.74, 95% CI 0.62–0.88, P=0.001). However,...