Expression of Heat Shock Protein-27 (HSP27) is reduced in human coronary atherosclerosis. Over-expression of HSP27 is protective against the early formation of lesions in atherosclerosis-prone apoE(-/-) mice (apoE(-/-)HSP27(o/e)) - however, only in females. We now seek to determine if chronic HSP27 over-expression is protective in a model of advanced atherosclerosis in both male and female apoE(-/-) mice.After 12 weeks on a high fat diet, serum HSP27 levels rose more than 16-fold in male and female apoE(-/-)HSP27(o/e) mice, although females had higher levels than males. Relative to apoE(-/-) mice, female apoE(-/-)HSP27(o/e) mice showed reductions in aortic lesion area of 35% for en face and 30% for cross-sectional sinus tissue sections - wi...
The heat shock proteins (HSPs) are highly conserved families of proteins expressed by a number of ce...
Atherosclerosis is the leading global cause of mortality, morbidity, and disability. Heat shock prot...
OBJECTIVE: Genetic ablation of the growth suppressor p27(Kip1) (p27) in the mouse aggravates atheros...
mice. counterparts.Chronic over-expression of HSP27 is atheroprotective in both sexes and coincides...
ObjectivesThe aim of this study was to evaluate the potential of serum heat shock protein 27 (HSP27)...
Atherosclerosis is a chronic inflammatory disease and autoimmune mechanisms may contribute to its pa...
The O’Brien lab has demonstrated that Heat shock protein 27 (HSP27)shows attenuated expression in hu...
Heat shock protein (HSP)27 is traditionally described as an intracellular chaperone and signaling mo...
In the study, we investigate whether the expressions of heat shock protein (hsp)60 (a potential auto...
Heat shock protein 27 (HSP27) has a major role in mediating survival responses to a range of central...
Heat shock proteins are molecular chaperones that have an ability to protect proteins from damage in...
Objectives. Elevated plasma homocysteine (Hcy) could lead to endothelial dysfunction and is viewed a...
Although challenging, neuroprotective therapies for ischemic stroke remain an interesting strategy f...
Heat-shock proteins are a family of proteins which are upregulated in response to stress stimuli inc...
Abstract Background Thoracic aortic dissection (TAD) is one of the most severe aortic diseases. The ...
The heat shock proteins (HSPs) are highly conserved families of proteins expressed by a number of ce...
Atherosclerosis is the leading global cause of mortality, morbidity, and disability. Heat shock prot...
OBJECTIVE: Genetic ablation of the growth suppressor p27(Kip1) (p27) in the mouse aggravates atheros...
mice. counterparts.Chronic over-expression of HSP27 is atheroprotective in both sexes and coincides...
ObjectivesThe aim of this study was to evaluate the potential of serum heat shock protein 27 (HSP27)...
Atherosclerosis is a chronic inflammatory disease and autoimmune mechanisms may contribute to its pa...
The O’Brien lab has demonstrated that Heat shock protein 27 (HSP27)shows attenuated expression in hu...
Heat shock protein (HSP)27 is traditionally described as an intracellular chaperone and signaling mo...
In the study, we investigate whether the expressions of heat shock protein (hsp)60 (a potential auto...
Heat shock protein 27 (HSP27) has a major role in mediating survival responses to a range of central...
Heat shock proteins are molecular chaperones that have an ability to protect proteins from damage in...
Objectives. Elevated plasma homocysteine (Hcy) could lead to endothelial dysfunction and is viewed a...
Although challenging, neuroprotective therapies for ischemic stroke remain an interesting strategy f...
Heat-shock proteins are a family of proteins which are upregulated in response to stress stimuli inc...
Abstract Background Thoracic aortic dissection (TAD) is one of the most severe aortic diseases. The ...
The heat shock proteins (HSPs) are highly conserved families of proteins expressed by a number of ce...
Atherosclerosis is the leading global cause of mortality, morbidity, and disability. Heat shock prot...
OBJECTIVE: Genetic ablation of the growth suppressor p27(Kip1) (p27) in the mouse aggravates atheros...