A genome-wide association study on obesity and obesity-related traits.
- Kai Wang
- Wei-Dong Li
- Clarence K Zhang
- Zuoheng Wang
- Joseph T Glessner
- Struan F A Grant
- Hongyu Zhao
- Hakon Hakonarson
- R Arlen Price
DOIAbstract
Large-scale genome-wide association studies (GWAS) have identified many loci associated with body mass index (BMI), but few studies focused on obesity as a binary trait. Here we report the results of a GWAS and candidate SNP genotyping study of obesity, including extremely obese cases and never overweight controls as well as families segregating extreme obesity and thinness. We first performed a GWAS on 520 cases (BMI>35 kg/m(2)) and 540 control subjects (BMI<25 kg/m(2)), on measures of obesity and obesity-related traits. We subsequently followed up obesity-associated signals by genotyping the top ∼500 SNPs from GWAS in the combined sample of cases, controls and family members totaling 2,256 individuals. For the binary trait of obesity, we ...
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