Background. Regulatory B cells (Breg) are a distinct B cell subset with immunoregulatory properties. Pivotal to Breg function is interleukin-10. This study was to investigate the role of IL-10-producing B cell (B10) and its association with Treg and Th17 subsets in immune thrombocytopenia (ITP) patients. Methods. Peripheral blood mononuclear cells from ITP patients and controls were stimulated with PMA, ionomycin, and Brefeldin A. The frequencies of CD19+IL-10+ B cells, CD3+CD4+IL-17+ Th17 cells, and CD4+CD25hiFoxp3+ Treg cells were analyzed by flow cytometry. The mRNA expression of Foxp3 and RORγt was detected by real-time quantitative PCR. Results. The number of B10 cells was elevated in ITP patients. After first-line therapies, it remain...
Primary immune thrombocytopenia (ITP) is an autoimmune disease characterised by premature platelet d...
BACKGROUND:Primary immune thrombocytopenia (ITP) is an autoimmune bleeding disorder with an unclear ...
Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy, whose immunological mechan...
Background: Primary immune thrombocytopenia (ITP) is an autoimmune heterogeneous disorder that is ch...
BACKGROUND: Primary immune thrombocytopenia (ITP) is an autoimmune heterogeneous disorder that is ch...
IL-17-secreting CD8+ T cells (Tc17 subset) have recently been defined as a subpopulation of effector...
possess immunoregulatory properties analogous to transitional B cells. IL-10–producing B cells are ...
OBJECTIVES: B cells have immunoregulatory function acting as antigen-presenting cells. A separate su...
A defective switching off of the immune response is involved in several autoimmune diseases. This sw...
In the last years, Th17 lymphocytes and regulatory B lymphocytes (Breg) seem to play a promising rol...
Regulatory B cells (Bregs) play a pivotal role in the maintenance of immune tolerance. Such critical...
Objectives. To investigate whether there is a direct relation between expanded proportions of Th17 e...
Immune thrombocytopenia (ITP) is a disease characterized by isolated thrombocytopenia. Abnormal effe...
This study had the objective to assess the frequency of Tregs in children newly diagnosed with ITP a...
Th17 and regulatory lymphocyte subsets such as Tregs and Bregs have been reported to play important ...
Primary immune thrombocytopenia (ITP) is an autoimmune disease characterised by premature platelet d...
BACKGROUND:Primary immune thrombocytopenia (ITP) is an autoimmune bleeding disorder with an unclear ...
Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy, whose immunological mechan...
Background: Primary immune thrombocytopenia (ITP) is an autoimmune heterogeneous disorder that is ch...
BACKGROUND: Primary immune thrombocytopenia (ITP) is an autoimmune heterogeneous disorder that is ch...
IL-17-secreting CD8+ T cells (Tc17 subset) have recently been defined as a subpopulation of effector...
possess immunoregulatory properties analogous to transitional B cells. IL-10–producing B cells are ...
OBJECTIVES: B cells have immunoregulatory function acting as antigen-presenting cells. A separate su...
A defective switching off of the immune response is involved in several autoimmune diseases. This sw...
In the last years, Th17 lymphocytes and regulatory B lymphocytes (Breg) seem to play a promising rol...
Regulatory B cells (Bregs) play a pivotal role in the maintenance of immune tolerance. Such critical...
Objectives. To investigate whether there is a direct relation between expanded proportions of Th17 e...
Immune thrombocytopenia (ITP) is a disease characterized by isolated thrombocytopenia. Abnormal effe...
This study had the objective to assess the frequency of Tregs in children newly diagnosed with ITP a...
Th17 and regulatory lymphocyte subsets such as Tregs and Bregs have been reported to play important ...
Primary immune thrombocytopenia (ITP) is an autoimmune disease characterised by premature platelet d...
BACKGROUND:Primary immune thrombocytopenia (ITP) is an autoimmune bleeding disorder with an unclear ...
Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy, whose immunological mechan...